Karsidag Sibel, Sahin Sevki, Ates Miruna F, Cinar Nilgun, Kendirli Sude
Neurology, Maltepe University, School of Medicine, Istanbul, TUR.
Cureus. 2021 Aug 19;13(8):e17297. doi: 10.7759/cureus.17297. eCollection 2021 Aug.
Neurological diseases related to coronavirus disease-2019 (COVID-19) are increasingly reported. We report here three cases that presented with subtle neurologic findings manifesting within a range of 15 days to four months after their COVID-19 diagnoses. Magnetic resonance imaging showed acute multifocal periventricular and subcortical demyelinating lesions. Some of the lesions showed contrast enhancement and diffusion restriction. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) PCR was found in the cerebrospinal fluid of just one patient. All patients received intravenous methylprednisolone therapy. In this report, we aim to discuss the aspects of possible COVID-19-related demyelination that support a diagnosis of multiple sclerosis (MS) or acute disseminated encephalomyelitis (ADEM).
与2019冠状病毒病（COVID-19）相关的神经系统疾病报告日益增多。我们在此报告3例病例，这些病例在COVID-19确诊后的15天至4个月内出现了细微的神经系统表现。磁共振成像显示急性多灶性脑室周围和皮质下脱髓鞘病变。部分病变有强化及扩散受限表现。仅1例患者的脑脊液中检测到严重急性呼吸综合征冠状病毒2（SARS-CoV-2）核酸。所有患者均接受了静脉注射甲泼尼龙治疗。在本报告中，我们旨在探讨可能与COVID-19相关的脱髓鞘方面，以支持多发性硬化（MS）或急性播散性脑脊髓炎（ADEM）的诊断。
