2019 年冠状病毒病（COVID-19）能否引发多发性硬化症恶化？一项回顾性研究。
Can coronavirus disease 2019 (COVID-19) trigger exacerbation of multiple sclerosis? A retrospective study.
机构信息
Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Student Research Committee, Faculty of Paramedicine, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Mult Scler Relat Disord. 2021 Jul;52:102947. doi: 10.1016/j.msard.2021.102947. Epub 2021 Apr 11.
Abstract
The effect of coronavirus disease (COVID-19) on the risk of relapse in multiple sclerosis (MS) have been unknown. In this retrospective study of 41 relapsing-remitting MS patients, number of relapses in pre-defined at risk-period (ARP) was compared with the previous two years. During the previous two years, a total of 32 attacks was reported, which 5 (15.6%) were during the at-risk period. After adjusting for age and sex, there was an increased risk of attack during ARP compared to the previous two years (RR: 2.566, 95%CI: 1.075-6.124, P=0.034). Our preliminary study suggested that COVID-19 can trigger exacerbation of MS.
摘要
新冠病毒疾病（COVID-19）对多发性硬化症（MS）复发风险的影响尚不清楚。在这项对 41 例复发缓解型 MS 患者的回顾性研究中，比较了预先定义的风险期（ARP）内的复发次数与前两年的情况。在过去两年中，共报告了 32 次发作，其中 5 次（15.6%）发生在风险期内。在调整年龄和性别后，ARP 期间的发作风险高于前两年（RR：2.566，95%CI：1.075-6.124，P=0.034）。我们的初步研究表明，COVID-19 可能引发 MS 恶化。
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