Department of Pathology, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.
Cancer Rep (Hoboken). 2022 Sep;5(9):e1561. doi: 10.1002/cnr2.1561. Epub 2021 Sep 23.
Pyroptosis plays a dual role in the development of cancer and malignancy; as such, it may potentially be a new target for cancer treatment. However, the inflammatory response to pyroptosis may have adverse effects on the body. The roles of gasdermin E (GSDME), caspases, and related proteins associated with pyroptosis in cancer remain controversial.
The goal of this study was to determine whether the expression levels of caspase-3 and GSDME affect the clinical stage, pathological grade, or survival prognosis of patients with lung cancer.
We examined the protein levels of GSDME, caspase-3, caspase-8, and caspase-9 in lung tissue samples from 100 patients with lung cancer by using immunohistochemistry.
We found that GSDME, caspase-3, and caspase-8 were more highly expressed in tumor tissues than in adjacent normal tissues. Moreover, we found that GSDME could serve as a prognostic factor as there was a positive correlation between its expression level and the postoperative survival rate of patients with lung cancer.
GSDME may be an independent factor affecting the prognosis of patients with lung cancer. However, the role of GSDME and its related proteins in cancer requires further research.
细胞焦亡在癌症的发生和恶性进展中起双重作用；因此，它可能成为癌症治疗的新靶点。然而，细胞焦亡引发的炎症反应可能对身体产生不良影响。Gasdermin E（GSDME）、半胱天冬酶（caspase）和与细胞焦亡相关的蛋白在癌症中的作用仍存在争议。
本研究旨在探讨 caspase-3 和 GSDME 的表达水平是否影响肺癌患者的临床分期、病理分级或生存预后。
采用免疫组化法检测 100 例肺癌患者肺组织中 GSDME、caspase-3、caspase-8 和 caspase-9 的蛋白水平。
我们发现 GSDME、caspase-3 和 caspase-8 在肿瘤组织中的表达水平高于癌旁正常组织。此外，我们发现 GSDME 可作为一个预后因素，因为它的表达水平与肺癌患者的术后生存率呈正相关。
GSDME 可能是影响肺癌患者预后的独立因素。然而，GSDME 及其相关蛋白在癌症中的作用需要进一步研究。
