COVID-19 的皮肤病理学：疾病免疫机制的窗口。
Cutaneous Pathology of COVID-19 as a Window into Immunologic Mechanisms of Disease.
机构信息
Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA; Medical Scientist Training Program, University of California, San Francisco, 513 Parnassus Avenue, Room HSE1001A, San Francisco, CA 94143, USA.
Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA; Department of Dermatology, University of California, San Francisco, 513 Parnassus Avenue, Room HSE1001E, San Francisco, CA 94143, USA.
出版信息
Dermatol Clin. 2021 Oct;39(4):533-543. doi: 10.1016/j.det.2021.05.008. Epub 2021 Jul 22.
Many skin manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection reflect activation of cutaneous and systemic immune responses involving effector pathways of both the innate and adaptive arms of the immune system. This article reviews evidence from the recent clinical and scientific literature that informs the current understanding of the consequences of coronavirus disease 2019 (COVID-19)-induced immune cell activation, as relevant to dermatology. Topics include the clinical consequences of autoantibody production in patients with COVID-19, immunologic evidence for chilblains as a manifestation of SARS-CoV-2 infection, and the relationship between type I interferons and COVID-19 disease severity.
许多严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染的皮肤表现反映了皮肤和全身免疫反应的激活，涉及固有免疫和适应性免疫的效应途径。本文综述了最近临床和科学文献中的证据，这些证据使我们对 2019 年冠状病毒病（COVID-19）引起的免疫细胞激活的后果有了目前的认识，这与皮肤病学有关。讨论的主题包括 COVID-19 患者自身抗体产生的临床后果、冻疮作为 SARS-CoV-2 感染表现的免疫学证据，以及 I 型干扰素与 COVID-19 疾病严重程度的关系。
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