Alvarenga Kátia de Freitas, Duarte Josilene Luciene, Silva Daniela Polo Camargo da, Agostinho-Pesse Raquel Sampaio, Negrato Carlos Antonio, Costa Orozimbo Alves
Braz J Otorhinolaryngol. 2005 Mar-Apr;71(2):202-7. doi: 10.1016/s1808-8694(15)31311-2. Epub 2005 Aug 2.
Diabetes Mellitus may lead to alterations in the eyes, kidneys, cranial nerves, peripheral nerves, ears etc. The cognitive function also seems to be compromised in subjects presented with Diabetes Mellitus, since the cortical and subcortical structures responsible for this function are hindered in some insulin-dependent patients. The cognitive potential P300 has been used as an objective procedure to assess cerebral cognitive functions.
To analyze the sensitivity of P300 cognitive potential for the detection of alterations on the auditory cortex secondary to Diabetes Mellitus.
transversal cohort.
Sixteen diabetic subjects of both genders aged 7 to 71 years, and seventeen non-diabetic individuals at the same age range participated in this study. The evaluation procedures were pure tone audiometry (PTA) and P300 cognitive potential. Glycemia of the group presented with Diabetes was assessed prior to applying P300.
No statistically significant difference was shown for PTA results. A statically significant difference was observed between groups when analyzing the latency of P300 component measured in Fz. There was a correlation between glycemia and latency and amplitude of P300.
The investigation of the cognitive potential of P300 is an important procedure for prevention and early diagnosis of neurological changes in individuals presented with Diabetes Mellitus.
糖尿病可能导致眼睛、肾脏、颅神经、周围神经、耳朵等部位发生病变。糖尿病患者的认知功能似乎也会受到损害，因为在一些胰岛素依赖型患者中，负责该功能的皮质和皮质下结构会受到阻碍。认知电位P300已被用作评估大脑认知功能的客观方法。
分析P300认知电位对检测糖尿病继发听觉皮层改变的敏感性。
横向队列研究。
16名年龄在7至71岁的糖尿病患者（男女均有）和17名年龄范围相同的非糖尿病个体参与了本研究。评估程序包括纯音听力测定（PTA）和P300认知电位。在应用P300之前评估糖尿病组的血糖水平。
PTA结果无统计学显著差异。分析在Fz处测量的P300成分的潜伏期时，两组之间存在统计学显著差异。血糖与P300的潜伏期和波幅之间存在相关性。
对P300认知电位的研究是预防和早期诊断糖尿病患者神经病变的重要方法。
