Sahoo Debee Prasad, Van Winkle Lon J, Díaz de la Garza Rocío I, Dubrovsky Joseph G
Departamento de Biología Molecular de Plantas, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Mexico.
Department of Biochemistry, Midwestern University, Downers Grove, IL, United States.
Front Cell Dev Biol. 2021 Sep 7;9:672545. doi: 10.3389/fcell.2021.672545. eCollection 2021.
In multicellular organisms, tissue generation, maintenance, and homeostasis depend on stem cells. Cellular metabolic status is an essential component of different differentiated states, from stem to fully differentiated cells. Threonine (Thr) metabolism has emerged as a critical factor required to maintain pluripotent/multipotent stem cells in both plants and animals. Thus, both kingdoms conserved or converged upon this fundamental feature of stem cell function. Here, we examine similarities and differences in Thr metabolism-dependent mechanisms supporting stem cell maintenance in these two kingdoms. We then consider common features of Thr metabolism in stem cell maintenance and predict and speculate that some knowledge about Thr metabolism and its role in stem cell function in one kingdom may apply to the other. Finally, we outline future research directions to explore these hypotheses.
在多细胞生物中，组织的生成、维持和内稳态依赖于干细胞。细胞代谢状态是从干细胞到完全分化细胞的不同分化状态的重要组成部分。苏氨酸（Thr）代谢已成为维持植物和动物多能/多潜能干细胞所需的关键因素。因此，这两个王国在干细胞功能的这一基本特征上保持了一致或趋同。在这里，我们研究了支持这两个王国干细胞维持的苏氨酸代谢依赖性机制的异同。然后，我们考虑了苏氨酸代谢在干细胞维持中的共同特征，并预测和推测关于一个王国中苏氨酸代谢及其在干细胞功能中的作用的一些知识可能适用于另一个王国。最后，我们概述了未来探索这些假设的研究方向。
