仅局限于H-2K基因突变的遗传差异对小鼠妊娠阻断发生率的影响。
Influence of a genetic difference confined to mutation of H-2K on the incidence of pregnancy block in mice.
作者信息
Yamazaki K, Beauchamp G K, Matsuzaki O, Kupniewski D, Bard J, Thomas L, Boyse E A
出版信息
Proc Natl Acad Sci U S A. 1986 Feb;83(3):740-1. doi: 10.1073/pnas.83.3.740.
Abstract
In mice, pregnancy is often terminated when the stud male is removed and the pregnant female is exposed to the presence or scent of an unfamiliar male. It is reported here that the incidence of such blocking of pregnancy was higher when the stud and unfamiliar male differed by mutation of the H-2K class I gene of the major histocompatibility complex than when the stud and unfamiliar males were genetically identical. Thus, the olfactory distinction of mice differing by mutation of the H-2K gene, previously demonstrated after training of mice in a Y maze, can spontaneously influence neuroendocrine communications affecting reproduction.
摘要
在小鼠中，当移除种雄并使怀孕雌鼠接触陌生雄鼠的存在或气味时，妊娠常常会终止。据本文报道，当种雄和陌生雄鼠在主要组织相容性复合体的H-2K I类基因上发生突变而存在差异时，这种妊娠阻断的发生率高于种雄和陌生雄鼠基因相同时的情况。因此，先前在Y迷宫中对小鼠进行训练后所证明的，因H-2K基因突变而存在差异的小鼠的嗅觉辨别能力，能够自发地影响影响生殖的神经内分泌通讯。
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本文引用的文献
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The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events.一个突变的H-2基因的结构表明，H-2基因多态性的产生可能是通过类似基因转换的事件发生的。
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