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小鼠X和Y染色体参与基因决定的化学感应特性形成。

Participation of the murine X and Y chromosomes in genetically determined chemosensory identity.

作者信息

Yamazaki K, Beauchamp G K, Matsuzaki O, Bard J, Thomas L, Boyse E A

出版信息

Proc Natl Acad Sci U S A. 1986 Jun;83(12):4438-40. doi: 10.1073/pnas.83.12.4438.

Abstract

The major histocompatibility complex of the mouse imparts to each mouse an odor that reflects its genetic constitution at this region of chromosome 17. Sensory recognition of these differential odors influences reproductive behavior and evokes neuroendocrine responses critical to the maintenance of pregnancy. To determine whether other parts of the mouse genome contribute to individual scent marking, and so may similarly exert a selective force on loci other than the major histocompatibility complex, mice differing genetically only in their X and/or Y chromosomes were tested for individuality of scent in the Y-maze system previously employed to investigate major histocompatibility complex-related scent distinctions. It is shown that the X and Y chromosomes each confer individually of scent related to genotype.

摘要

小鼠的主要组织相容性复合体赋予每只小鼠一种气味,这种气味反映了其在17号染色体该区域的基因构成。对这些不同气味的感官识别会影响生殖行为,并引发对维持妊娠至关重要的神经内分泌反应。为了确定小鼠基因组的其他部分是否对个体气味标记有贡献,从而可能同样对主要组织相容性复合体以外的基因座施加选择压力,我们在先前用于研究与主要组织相容性复合体相关的气味差异的Y迷宫系统中,对仅在X和/或Y染色体上存在基因差异的小鼠进行了气味个体性测试。结果表明,X染色体和Y染色体各自独立赋予与基因型相关的气味。

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