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液体活检在肿瘤、神经退行性疾病和肌肉退行性疾病中的潜在价值与应用。

Potential Value and Application of Liquid Biopsy in Tumor, Neurodegeneration, and Muscle Degenerative Diseases.

机构信息

Department of Health and Physical Education, Jianghan University, Wuhan, Hubei, People's Republic of China.

Jianghan University Library, Wuhan, Hubei, People's Republic of China.

出版信息

Methods Mol Biol. 2023;2695:317-335. doi: 10.1007/978-1-0716-3346-5_22.

Abstract

Liquid biopsy provides a promising alternative for the detection of disease-specific markers due to its superior noninvasive and original tissue representativeness. Liquid biopsies have a wide range of health and disease applications involving components ranging from circulating cells to acellular nucleic acid molecules and other metabolites. Here, we review the different components of liquid biopsy and investigate the most advanced noninvasive methods for detecting these components as well as their existing problems and trends. In particular, we emphasize the importance of analyzing liquid biopsy data from extracellular vesicles and small nucleic acids in neurological and muscle degeneration, with the aim of using this technique to enhance personalized healthcare. Although previous reviews have focused on cancer, this review mainly emphasizes the potential application of extracellular vesicles and microRNAs in liquid biopsy in neurodegeneration and muscle degeneration.

摘要

液体活检因其具有优越的非侵入性和原始组织代表性,为疾病特异性标志物的检测提供了一种很有前途的替代方法。液体活检在健康和疾病应用方面具有广泛的应用,涉及从循环细胞到无细胞核酸分子和其他代谢物等多种成分。在这里,我们综述了液体活检的不同成分,并研究了检测这些成分的最先进的无创方法及其存在的问题和趋势。特别是,我们强调了分析神经和肌肉退行性疾病中外泌体和小核酸液体活检数据的重要性,目的是利用该技术增强个性化医疗。虽然之前的综述主要集中在癌症方面,但本综述主要强调了外泌体和 microRNAs 在神经退行性疾病和肌肉退行性疾病液体活检中的潜在应用。

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