State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
Biosensors (Basel). 2021 Aug 27;11(9):299. doi: 10.3390/bios11090299.
Though there already had been notable progress in developing efficient therapeutic strategies for cancers, there still exist many requirements for significant improvement of the safety and efficiency of targeting cancer treatment. Thus, the rational design of a fully biodegradable and synergistic bioimaging and therapy system is of great significance. Metal organic framework (MOF) is an emerging class of coordination materials formed from metal ion/ion clusters nodes and organic ligand linkers. It arouses increasing interest in various areas in recent years. The unique features of adjustable composition, porous and directional structure, high specific surface areas, biocompatibility, and biodegradability make it possible for MOFs to be utilized as nano-drugs or/and nanocarriers for multimodal imaging and therapy. This review outlines recent advances in developing MOFs for multimodal treatment of cancer and discusses the prospects and challenges ahead.
尽管在开发癌症有效治疗策略方面已经取得了显著进展，但仍需要显著提高靶向癌症治疗的安全性和效率。因此，合理设计完全可生物降解和协同的生物成像和治疗系统具有重要意义。金属有机骨架（MOF）是由金属离子/离子簇节点和有机配体连接物组成的一类新兴配位材料。近年来，它在各个领域引起了越来越多的兴趣。MOF 的组成可调节、多孔和定向结构、高比表面积、生物相容性和可生物降解性等独特特性使其有可能被用作多模式成像和治疗的纳米药物或/和纳米载体。本综述概述了用于癌症多模式治疗的 MOF 的最新进展，并讨论了未来的前景和挑战。
