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Tenascin-C 在肌层浸润性膀胱癌淋巴结前转移灶中的表达。

Tenascin-C expression in the lymph node pre-metastatic niche in muscle-invasive bladder cancer.

机构信息

Department of Urology, University of Rochester Medical Center, Rochester, NY, USA.

Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.

出版信息

Br J Cancer. 2021 Nov;125(10):1399-1407. doi: 10.1038/s41416-021-01554-z. Epub 2021 Sep 25.

DOI:10.1038/s41416-021-01554-z
PMID:34564696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8575937/
Abstract

BACKGROUND

Markers of stromal activation at future metastatic sites may have prognostic value and may allow clinicians to identify and abolish the pre-metastatic niche to prevent metastasis. In this study, we evaluate tenascin-C as a marker of pre-metastatic niche formation in bladder cancer patient lymph nodes.

METHODS

Tenascin-C expression in benign lymph nodes was compared between metastatic (n = 20) and non-metastatic (n = 27) patients with muscle-invasive bladder cancer. Urinary extracellular vesicle (EV) cytokine levels were measured with an antibody array to examine potential correlation with lymph node inflammation. The ability of bladder cancer EVs to activate primary bladder fibroblasts was assessed in vitro.

RESULTS

Lymph node tenascin-C expression was elevated in metastatic patients vs. non-metastatic patients, and high expression was associated with worse survival. Urinary EVs contained four cytokines that were positively correlated with lymph node tenascin-C expression. Bladder cancer EVs induced tenascin-C expression in fibroblasts in an NF-κB-dependent manner.

CONCLUSIONS

Tenascin-C expression in regional lymph nodes may be a good predictor of bladder cancer metastasis and an appropriate imaging target. It may be possible to interrupt pre-metastatic niche formation by targeting EV-borne tumour cytokines or by targeting tenascin-C directly.

摘要

背景

未来转移部位基质激活的标志物可能具有预后价值，并使临床医生能够识别和消除前转移龛，以预防转移。在这项研究中，我们评估了 tenascin-C 作为膀胱癌患者淋巴结前转移龛形成的标志物。

方法

比较了肌层浸润性膀胱癌转移（n=20）和非转移（n=27）患者良性淋巴结中的 tenascin-C 表达。通过抗体阵列测量尿细胞外囊泡（EV）细胞因子水平，以检查与淋巴结炎症的潜在相关性。评估膀胱癌 EV 在体外激活原代膀胱成纤维细胞的能力。

结果

转移性患者的淋巴结 tenascin-C 表达高于非转移性患者，高表达与生存率降低相关。尿 EV 中含有四种细胞因子，与淋巴结 tenascin-C 表达呈正相关。膀胱癌 EV 以 NF-κB 依赖的方式诱导成纤维细胞中 tenascin-C 的表达。

结论

区域淋巴结中的 tenascin-C 表达可能是膀胱癌转移的良好预测因子，也是合适的成像靶标。通过靶向 EV 携带的肿瘤细胞因子或直接靶向 tenascin-C，可能有可能阻断前转移龛的形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab00/8575937/b4d46ae53287/41416_2021_1554_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab00/8575937/fd25f78e312d/41416_2021_1554_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab00/8575937/494106744dda/41416_2021_1554_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab00/8575937/b4d46ae53287/41416_2021_1554_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab00/8575937/fd25f78e312d/41416_2021_1554_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab00/8575937/494106744dda/41416_2021_1554_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab00/8575937/b4d46ae53287/41416_2021_1554_Fig3_HTML.jpg

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本文引用的文献

1
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Front Immunol. 2021 Apr 26;12:671485. doi: 10.3389/fimmu.2021.671485. eCollection 2021.
2
Novel Human Tenascin-C Function-Blocking Camel Single Domain Nanobodies.新型人 tenascin-C 功能阻断骆驼单域纳米抗体。
Front Immunol. 2021 Mar 15;12:635166. doi: 10.3389/fimmu.2021.635166. eCollection 2021.
3
Exosomal Long Non-coding RNAs: Emerging Players in the Tumor Microenvironment.
开发一种与干性相关的预后指数以提供膀胱癌的治疗策略。
NPJ Precis Oncol. 2024 Jan 20;8(1):14. doi: 10.1038/s41698-024-00510-3.
4
Extracellular Vesicles: Biological Packages That Modulate Tumor Cell Invasion.细胞外囊泡：调节肿瘤细胞侵袭的生物包裹体
Cancers (Basel). 2023 Nov 28;15(23):5617. doi: 10.3390/cancers15235617.
5
Diverse activity of miR-150 in Tumor development: shedding light on the potential mechanisms.miR-150在肿瘤发展中的多样活性：揭示潜在机制
Cancer Cell Int. 2023 Nov 3;23(1):261. doi: 10.1186/s12935-023-03105-3.
6
Cellular and molecular characteristics of the premetastatic niches.转移前生态位的细胞和分子特征。
Animal Model Exp Med. 2023 Oct;6(5):399-408. doi: 10.1002/ame2.12356.
7
The role of cancer-associated fibroblasts in bladder cancer progression.癌症相关成纤维细胞在膀胱癌进展中的作用。
Heliyon. 2023 Sep 4;9(9):e19802. doi: 10.1016/j.heliyon.2023.e19802. eCollection 2023 Sep.
8
The Bladder Tumor Microenvironment Components That Modulate the Tumor and Impact Therapy.膀胱肿瘤微环境成分调节肿瘤并影响治疗。
Int J Mol Sci. 2023 Aug 1;24(15):12311. doi: 10.3390/ijms241512311.
9
Tumor-derived Cav-1 promotes pre-metastatic niche formation and lung metastasis in breast cancer.肿瘤源性 Cav-1 促进乳腺癌前转移龛形成和肺转移。
Theranostics. 2023 Mar 13;13(5):1684-1697. doi: 10.7150/thno.79250. eCollection 2023.
10
Immune determinants of the pre-metastatic niche.转移前生态位的免疫决定因素。
Cancer Cell. 2023 Mar 13;41(3):546-572. doi: 10.1016/j.ccell.2023.02.018.
外泌体长链非编码RNA：肿瘤微环境中的新兴参与者
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5
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Int Heart J. 2019 Jan 25;60(1):151-158. doi: 10.1536/ihj.17-734. Epub 2018 Nov 20.
7
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8
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Mol Cancer Res. 2018 Jul;16(7):1196-1204. doi: 10.1158/1541-7786.MCR-17-0784. Epub 2018 Apr 10.
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Acta Radiol. 2018 Dec;59(12):1431-1437. doi: 10.1177/0284185118762613. Epub 2018 Mar 22.
10
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Oncotarget. 2017 Aug 8;8(53):91199-91208. doi: 10.18632/oncotarget.20043. eCollection 2017 Oct 31.