Wu Wei-Tao, Zhussupbekov Mansur, Aubry Nadine, Antaki James F, Massoudi Mehrdad
School of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing, J.S., 210094, China.
Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA.
Int J Eng Sci. 2020 Feb;147. doi: 10.1016/j.ijengsci.2019.103206. Epub 2019 Dec 20.
This study was undertaken to develop a numerical/computational simulation of von Willebrand Factor (vWF) - mediated platelet shear activation and deposition in an idealized stenosis. Blood is treated as a multi-constituent mixture comprised of a linear fluid component and a porous solid component (thrombus). Chemical and biological species involved in coagulation are modeled using a system of coupled convection-reaction-diffusion (CRD) equations. This study considers the cumulative effect of shear stress (history) on platelet activation. The vWF activity is modeled as an enhancement function for the shear stress accumulation and is related to the experimentally-observed unfolding rate of vWF. A series of simulations were performed in an idealized stenosis in which the predicted platelets deposition agreed well with previous experimental observations spatially and temporally, including the reduction of platelet deposition with decreasing expansion angle. Further simulation indicated a direct relationship between vWF-mediated platelet deposition and degree of stenosis. Based on the success with these benchmark simulations, it is hoped that the model presented here may provide additional insight into vWF-mediated thrombosis and prove useful for the development of more hemo-compatible blood-wetted devices in the future.
本研究旨在对理想化狭窄血管中血管性血友病因子（vWF）介导的血小板剪切激活和沉积进行数值/计算模拟。血液被视为由线性流体成分和多孔固体成分（血栓）组成的多组分混合物。参与凝血的化学和生物物质使用耦合对流-反应-扩散（CRD）方程组进行建模。本研究考虑了剪切应力（历史）对血小板激活的累积效应。vWF活性被建模为剪切应力积累的增强函数，并与实验观察到的vWF解折叠速率相关。在理想化狭窄血管中进行了一系列模拟，其中预测的血小板沉积在空间和时间上与先前的实验观察结果吻合良好，包括随着扩张角度减小血小板沉积减少。进一步的模拟表明vWF介导的血小板沉积与狭窄程度之间存在直接关系。基于这些基准模拟的成功，希望本文提出的模型能够为vWF介导的血栓形成提供更多见解，并在未来对开发更具血液相容性的血液接触装置有用。
