Cagle Jackson N, Wong Joshua K, Johnson Kara A, Foote Kelly D, Okun Michael S, de Hemptinne Coralie
Department of Neurology, University of Florida, Gainesville, FL, United States.
Norman Fixel Institute for Neurological Diseases, Gainesville, FL, United States.
Front Hum Neurosci. 2021 Sep 9;15:749567. doi: 10.3389/fnhum.2021.749567. eCollection 2021.
Pallidal deep brain stimulation (DBS) is an increasingly used therapy for Parkinson's disease (PD). Here, we study the effect of DBS on pallidal oscillatory activity as well as on symptom severity in an individual with PD implanted with a new pulse generator (Medtronic Percept system) which facilitates chronic recording of local field potentials (LFP) through implanted DBS lead. Pallidal LFPs were recorded while delivering stimulation in a monopolar configuration using stepwise increments (0.5 mA, every 20 s). At each stimulation amplitude, the power spectral density (PSD) was computed, and beta power (13-30 Hz) was calculated and correlated with the degree of bradykinesia. Pallidal beta power was reduced when therapeutic stimulation was delivered. Beta power correlated to the severity of bradykinesia. Worsening of parkinsonism when excessive stimulation was applied was associated with a rebound in the beta band power. These preliminary results suggest that pallidal beta power might be used as an objective marker of the disease state in PD. The use of brain sensing from implanted neural interfaces may in the future facilitate clinical programming. Detection of rebound could help to optimize benefits and minimize worsening from overstimulation.
苍白球深部脑刺激（DBS）是一种越来越多地用于治疗帕金森病（PD）的疗法。在此，我们研究了DBS对一名植入了新型脉冲发生器（美敦力Percept系统）的PD患者苍白球振荡活动以及症状严重程度的影响，该系统有助于通过植入的DBS电极慢性记录局部场电位（LFP）。在使用逐步增量（0.5 mA，每20秒）以单极配置进行刺激时记录苍白球LFP。在每个刺激幅度下，计算功率谱密度（PSD），并计算β功率（13 - 30 Hz），并将其与运动迟缓程度相关联。当进行治疗性刺激时，苍白球β功率降低。β功率与运动迟缓的严重程度相关。当施加过度刺激时帕金森症状加重与β波段功率反弹有关。这些初步结果表明，苍白球β功率可能用作PD疾病状态的客观标志物。未来，利用植入神经接口进行脑传感可能有助于临床编程。检测到反弹有助于优化益处并将过度刺激导致的恶化降至最低。
