El Houari Ilias, Boerjan Wout, Vanholme Bartel
Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
VIB Center for Plant Systems Biology, Ghent, Belgium.
Front Plant Sci. 2021 Sep 9;12:734070. doi: 10.3389/fpls.2021.734070. eCollection 2021.
The phenylpropanoid pathway converts the aromatic amino acid phenylalanine into a wide range of secondary metabolites. Most of the carbon entering the pathway incorporates into the building blocks of lignin, an aromatic polymer providing mechanical strength to plants. Several intermediates in the phenylpropanoid pathway serve as precursors for distinct classes of metabolites that branch out from the core pathway. Untangling this metabolic network in Arabidopsis was largely done using phenylpropanoid pathway mutants, all with different degrees of lignin depletion and associated growth defects. The phenotypic defects of some phenylpropanoid pathway mutants have been attributed to differentially accumulating phenylpropanoids or phenylpropanoid-derived compounds. In this perspectives article, we summarize and discuss the reports describing an altered accumulation of these bioactive molecules as the causal factor for the phenotypes of lignin mutants in Arabidopsis.
苯丙烷途径将芳香族氨基酸苯丙氨酸转化为多种次生代谢产物。进入该途径的大部分碳会整合到木质素的组成部分中，木质素是一种为植物提供机械强度的芳香族聚合物。苯丙烷途径中的几种中间产物作为不同类别的代谢产物的前体，这些代谢产物从核心途径分支出来。在拟南芥中解析这个代谢网络主要是利用苯丙烷途径突变体完成的，所有这些突变体都有不同程度的木质素减少以及相关的生长缺陷。一些苯丙烷途径突变体的表型缺陷被归因于苯丙烷类化合物或苯丙烷衍生化合物的差异积累。在这篇观点文章中，我们总结并讨论了那些将这些生物活性分子积累的改变描述为拟南芥木质素突变体表型的因果因素的报告。
