Environmental Exposure to Heavy Metals Contributes to Diseases Via Deregulated Wnt Signaling Pathways.

signaling plays a critical role during embryogenesis and is responsible for regulating the homeostasis of the adult stem cells and cells fate via a multitude of signaling pathways and associated transcription factors, receptors, effectors, and inhibitors. For this review, published articles were searched from PubMed Central, Embase, Medline, and Google Scholar. The search terms were , canonical, noncanonical, signaling pathway, , environment, and heavy metals. Published articles on signaling pathways and heavy metals as contributing factors for causing diseases via influencing signaling pathways were included. canonical or noncanonical signaling pathways are the key regulators of stem cell homeostasis that control many mechanisms. There is an adequate balance between dependent and independent signaling pathways and remain highly conserved throughout different development stages. Environmental heavy metal exposure may cause either inhibition or overexpression of any component of signaling pathways such as protein, transcription factors, receptors, ligands, or transducers to impede normal cellular function via negatively affecting signaling pathways. Environmental exposure to heavy metals potentially contributes to diseases via deregulated signaling pathways.