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不可逆电穿孔单独及与免疫疗法联合在胰腺癌中的免疫调节作用

Immunomodulatory Effect of Irreversible Electroporation Alone and Its Cooperating With Immunotherapy in Pancreatic Cancer.

作者信息

Tian Guo, Guan Jiajia, Chu Yanhua, Zhao Qiyu, Jiang Tian'an

机构信息

Department of Ultrasound Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Department of Biomedicine, Key Laboratory of Pulsed Power Translational Medicine of Zhejiang Province, Hangzhou, China.

出版信息

Front Oncol. 2021 Sep 10;11:712042. doi: 10.3389/fonc.2021.712042. eCollection 2021.

DOI:10.3389/fonc.2021.712042
PMID:34568040
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8462269/
Abstract

Emerging studies have showed irreversible electroporation (IRE) focused on pancreatic cancer (PC). However, the effects of IRE treatment on the immune response of PC remain unknown. Moreover, there are few studies on the therapeutic effect of IRE combining with immunotherapy on PC. Thus, we review recent advances in our understanding of IRE alone and its working with immunotherapy towards the immune response of PC, discussing potential opportunities for exploring future treatment strategies.

摘要

新兴研究表明，不可逆电穿孔（IRE）主要针对胰腺癌（PC）。然而，IRE治疗对PC免疫反应的影响尚不清楚。此外，关于IRE联合免疫疗法对PC治疗效果的研究很少。因此，我们回顾了目前对IRE单独及其与免疫疗法协同作用于PC免疫反应的最新认识进展，探讨未来治疗策略的潜在机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb65/8462269/766f50587cbb/fonc-11-712042-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb65/8462269/534e0296178d/fonc-11-712042-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb65/8462269/766f50587cbb/fonc-11-712042-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb65/8462269/534e0296178d/fonc-11-712042-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb65/8462269/766f50587cbb/fonc-11-712042-g002.jpg

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New therapeutic strategy: Personalization of pancreatic cancer treatment-irreversible electroporation (IRE), electrochemotherapy (ECT) and calcium electroporation (CaEP) - A pilot preclinical study.新的治疗策略：胰腺癌治疗的个性化——不可逆电穿孔（IRE）、电化学疗法（ECT）和钙电穿孔（CaEP）——一项临床前初步研究。
Surg Oncol. 2021 Sep;38:101634. doi: 10.1016/j.suronc.2021.101634. Epub 2021 Jul 21.
2
Irreversible electroporation ablation overcomes tumor-associated immunosuppression to improve the efficacy of DC vaccination in a mice model of pancreatic cancer.不可逆电穿孔消融克服肿瘤相关免疫抑制，以提高胰腺癌小鼠模型中树突状细胞疫苗接种的疗效。
Oncoimmunology. 2021 Feb 2;10(1):1875638. doi: 10.1080/2162402X.2021.1875638.
3
医学中的脉冲场消融：不可逆电穿孔和电通透理论与应用
Radiol Oncol. 2025 Feb 27;59(1):1-22. doi: 10.2478/raon-2025-0011. eCollection 2025 Mar 1.
4
How to Use Macrophages Against Cancer.如何利用巨噬细胞对抗癌症。
Cells. 2024 Nov 23;13(23):1948. doi: 10.3390/cells13231948.
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Clinical Insights and Future Prospects: A Comprehensive Narrative Review on Immunomodulation Induced by Electrochemotherapy.临床洞察与未来展望：电化学免疫调节的全面叙述性综述。
Curr Oncol. 2024 Oct 21;31(10):6433-6444. doi: 10.3390/curroncol31100478.
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Neoadjuvant chemo-immunotherapy is improved with a novel pulsed electric field technology in an immune-cold murine model.新辅助化疗免疫治疗在免疫冷的小鼠模型中通过新型脉冲电场技术得到改善。
PLoS One. 2024 Mar 25;19(3):e0299499. doi: 10.1371/journal.pone.0299499. eCollection 2024.
7
The Emerging Landscape for Combating Resistance Associated with Energy-Based Therapies via Nanomedicine.通过纳米医学对抗与能量疗法相关的耐药性的新兴领域。
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