阿尔及利亚西北部结直肠癌的流行病学见解。

Epidemiological insights into colorectal cancer in northwestern Algeria.

作者信息

Herrag Salah Eddine El, Moulessehoul Soraya, Mehadji Douniazad El, Yekrou Djamila, Khaled Méghit Boumediène

机构信息

Laboratoire de Nutrition, Pathologie, Agro-Biotechnologie et Santé (Lab-NuPABS), Faculty of Natural and Life Sciences, Djillali Liabes University, Sidi Bel Abbes 22000, Algeria.

Department of Biology Rectorat Ex ITMA, Faculty of Natural and Life Sciences, Djillali Liabes University, BP 89, Sidi Bel Abbes 22000, Algeria.

出版信息

Ecancermedicalscience. 2024 Mar 21;18:1684. doi: 10.3332/ecancer.2024.1684. eCollection 2024.

DOI:10.3332/ecancer.2024.1684

PMID:38566765

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10984843/

Abstract

OBJECTIVES

The incidence of colorectal cancer (CRC) has exhibited regional variability in North Africa and the Middle East, with a steady increase in Algeria. Despite this trend, limited data exist on the epidemiology of CRC in northwestern Algeria. Our study aimed to investigate the epidemiological characteristics of CRC in this region.

METHODS

We conducted a retrospective study examining 255 confirmed CRC cases through medical records from patients at the Sidi Bel Abbes anti-cancer centre.

RESULTS

The mean age of the study participants was 59 ± 13 years. The results showed a higher incidence in males (57%) than in females, and colon (62%) than rectal cancer. Within this cohort, 47% had a pre-existing medical condition, while 39% had a family history of cancer. Adenocarcinomas were the prevailing histological subtype in 94% of CRC cases. Compared with colon cancer, rectal cancer was less often diagnosed at stage IV of the disease (OR = 0.75; 95% CI = 0.09, 4.86; = 0.8) and more likely in early-onset patients (OR = 2.27; 95% CI = 1.25, 4.17; = 0.007). Men were at a higher risk of being diagnosed with metastatic CRC primarily hepatic metastases (OR = 2.03; 95% CI = 1.07, 3.99; = 0.033) and pulmonary metastases (OR = 2.50; 95% CI = 1.07, 6.59; = 0.045).

CONCLUSION

This study may provide a comprehensive glimpse into CRC epidemiology in northwest Algeria. Understanding regional differences is the key to implementing specific preventive and interventional strategies.

摘要

目的

在北非和中东地区，结直肠癌（CRC）的发病率呈现出区域差异，阿尔及利亚的发病率呈稳步上升趋势。尽管有这一趋势，但关于阿尔及利亚西北部CRC流行病学的数据有限。我们的研究旨在调查该地区CRC的流行病学特征。

方法

我们进行了一项回顾性研究，通过西迪贝勒阿巴斯抗癌中心患者的病历，对255例确诊的CRC病例进行了检查。

结果

研究参与者的平均年龄为59±13岁。结果显示，男性（57%）的发病率高于女性，结肠癌（62%）的发病率高于直肠癌。在这个队列中，47%的人有既往病史，39%的人有癌症家族史。腺癌是94%的CRC病例中主要的组织学亚型。与结肠癌相比，直肠癌在疾病IV期的诊断率较低（OR = 0.75；95%CI = 0.09，4.86；P = 0.8），而在早发患者中更常见（OR = 2.27；95%CI = 1.25，4.17；P = 0.007）。男性被诊断为转移性CRC（主要是肝转移）的风险更高（OR = 2.03；95%CI = 1.07，3.99；P = 0.033）和肺转移（OR = 2.50；95%CI = 1.07，6.59；P = 0.045）。