Richardson William J, Rogers Jesse D, Spinale Francis G
Department of Bioengineering, Clemson University, Clemson, SC, United States.
Cardiovascular Translational Research Center, University of South Carolina School of Medicine and Columbia Veterans Affairs Health Care System, Columbia, SC, United States.
Front Cardiovasc Med. 2021 Sep 10;8:705100. doi: 10.3389/fcvm.2021.705100. eCollection 2021.
There is a critical need for interventions to control the development and remodeling of scar tissue after myocardial infarction. A significant hurdle to fibrosis-related therapy is presented by the complex spatial needs of the infarcted ventricle, namely that collagenous buildup is beneficial in the ischemic zone but detrimental in the border and remote zones. As a new, alternative approach, we present a case to develop self-adapting, mechano-sensitive drug targets in order to leverage local, microenvironmental mechanics to modulate a therapy's pharmacologic effect. Such approaches could provide self-tuning control to either promote fibrosis or reduce fibrosis only when and where it is beneficial to do so.
迫切需要采取干预措施来控制心肌梗死后瘢痕组织的发展和重塑。梗死心室复杂的空间需求给纤维化相关治疗带来了重大障碍，即胶原堆积在缺血区有益，但在边缘区和远隔区有害。作为一种新的替代方法，我们提出一个案例，即开发自适应、机械敏感的药物靶点，以便利用局部微环境力学来调节治疗的药理作用。这种方法可以提供自调节控制，仅在有利于促进纤维化或减少纤维化的时间和地点进行相应调节。
