描述囊性纤维化患儿的过敏特征。
Characterising the allergic profile of children with cystic fibrosis.
机构信息
Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
出版信息
Immun Inflamm Dis. 2022 Jan;10(1):60-69. doi: 10.1002/iid3.540. Epub 2021 Sep 27.
BACKGROUND
Cystic fibrosis (CF) is a genetic condition that affects multiple organ systems. Allergic bronchopulmonary aspergillosis (ABPA) is a well-recognised problem but other allergic conditions are less well documented in CF.
OBJECTIVE
To characterise the allergic profile of a cohort of children with CF, with a focus on those with ABPA.
METHODS
A cohort of children with CF were interviewed and retrospective data were collected regarding their allergic histories and other relevant clinical features.
RESULTS
The cohort included 37 children with median age of 9 years (interquartile range: 6-12). There was a history of ≥1 allergic condition(s) in 28/37 children (76%). The most common allergic condition was allergic rhinitis (AR) in 21/37 (57%) and 16 of these 21 children (76%) had another allergic condition. All children with ABPA (8) had another allergic condition. In some children ABPA exacerbations appeared to be seasonal, suggesting possible cross-sensitisation between Aspergillus fumigatus and aeroallergens associated with seasonal AR. Allergic conditions were also common in children with Pseudomonas aeruginosa infection.
背景
囊性纤维化（CF）是一种影响多个器官系统的遗传疾病。变应性支气管肺曲霉病（ABPA）是一种公认的问题，但 CF 中其他变应性疾病的记录较少。
目的
描述一组 CF 患儿的变应性特征，重点关注 ABPA 患儿。
方法
对一组 CF 患儿进行了访谈，并回顾性收集了有关其过敏史和其他相关临床特征的资料。
结果
该队列包括 37 名中位年龄为 9 岁（四分位距：6-12）的儿童。28/37 名儿童（76%）有≥1 种过敏史。最常见的过敏病是过敏性鼻炎（AR），在 21/37 名儿童中（57%），其中 16 名（76%）有另一种过敏病。所有 ABPA 患儿（8 例）均有另一种过敏病。在一些患儿中，ABPA 加重似乎具有季节性，提示可能存在烟曲霉与季节性 AR 相关的气传过敏原的交叉致敏。铜绿假单胞菌感染的患儿中也常见过敏病。
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