细胞内原生寄生虫中的钙信号转导。
Calcium signaling in intracellular protist parasites.
机构信息
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA; Department of Cellular Biology, University of Georgia, Athens, GA, USA.
出版信息
Curr Opin Microbiol. 2021 Dec;64:33-40. doi: 10.1016/j.mib.2021.09.002. Epub 2021 Sep 24.
Abstract
Calcium ion (Ca) signaling is one of the most frequently employed mechanisms of signal transduction by eukaryotic cells, and starts with either Ca release from intracellular stores or Ca entry through the plasma membrane. In intracellular protist parasites Ca signaling initiates a sequence of events that may facilitate their invasion of host cells, respond to environmental changes within the host, or regulate the function of their intracellular organelles. In this review we examine recent findings in Ca signaling in two groups of intracellular protist parasites that have been studied in more detail, the apicomplexan and the trypanosomatid parasites.
摘要
钙离子（Ca）信号转导是真核细胞信号转导最常用的机制之一，它始于细胞内储存库中 Ca 的释放或通过质膜的 Ca 内流。在细胞内原生动物寄生虫中，Ca 信号转导引发一系列事件，这些事件可能有助于它们入侵宿主细胞，对宿主内环境变化做出反应，或调节其细胞内细胞器的功能。在这篇综述中，我们检查了在两种已被更详细研究的细胞内原生动物寄生虫（顶复门和动基体门寄生虫）中 Ca 信号转导的最新发现。
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