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用于骨组织工程的乳清衍生多孔碳支架

Whey-Derived Porous Carbon Scaffolds for Bone Tissue Engineering.

作者信息

Llamas-Unzueta Raúl, Suárez Marta, Fernández Adolfo, Díaz Raquel, Montes-Morán Miguel A, Menéndez J Angel

机构信息

Instituto de Ciencia y Tecnología del Carbono (INCAR-CSIC), c/Francisco Pintado Fe, 26, 33011 Oviedo, Spain.

Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo (UO), Principado de Asturias, Avda de la Vega 4-6, 33940 El Entrego, Spain.

出版信息

Biomedicines. 2021 Aug 26;9(9):1091. doi: 10.3390/biomedicines9091091.

DOI:10.3390/biomedicines9091091
PMID:34572276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8465549/
Abstract

Porous carbon structures derived from whey powders are described and evaluated as potential scaffolds in bone tissue engineering. These materials have a porosity between 48% and 58%, with a hierarchical pore size distribution ranging from 1 to 400 micrometres. Compressive strength and elastic modulus are outstanding for such a porous material, being up to three times better than those of traditional HA or TCP scaffolds with similar porosities. They also present non-cytotoxic and bioactive behavior, due to their carbon-based composition that also includes some residual mineral salts content.

摘要

本文描述并评估了由乳清粉衍生而来的多孔碳结构作为骨组织工程中潜在支架的性能。这些材料的孔隙率在48%至58%之间，具有1至400微米的分级孔径分布。对于这样一种多孔材料而言，其抗压强度和弹性模量非常出色，比具有相似孔隙率的传统HA或TCP支架高出两倍。由于其基于碳的组成还包含一些残留的矿物盐成分，它们还表现出无细胞毒性和生物活性的特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/1fc51356ac3f/biomedicines-09-01091-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/ef6aafb50740/biomedicines-09-01091-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/9b40837dbb51/biomedicines-09-01091-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/d3c5967b4cc8/biomedicines-09-01091-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/f3ab77883aba/biomedicines-09-01091-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/953e0b4721cb/biomedicines-09-01091-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/8f67b542ebcc/biomedicines-09-01091-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/94a4c859ac96/biomedicines-09-01091-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/4ae5a4c883ec/biomedicines-09-01091-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/1fc51356ac3f/biomedicines-09-01091-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/ef6aafb50740/biomedicines-09-01091-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/9b40837dbb51/biomedicines-09-01091-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/d3c5967b4cc8/biomedicines-09-01091-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/f3ab77883aba/biomedicines-09-01091-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/953e0b4721cb/biomedicines-09-01091-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/8f67b542ebcc/biomedicines-09-01091-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/94a4c859ac96/biomedicines-09-01091-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/4ae5a4c883ec/biomedicines-09-01091-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f52/8465549/1fc51356ac3f/biomedicines-09-01091-g009.jpg

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