Oliva Rossella, Budisavljević Sanja, Castiello Umberto, Begliomini Chiara
Centro Terapia e Ricerca sui Disturbi Alimentari (Center for Eating Disorders Therapy and Research-CenTeR Disturbi Alimentari), 30172 Venice, Italy.
School of Medicine, University of St Andrews, St Andrews KY16 9BA, UK.
Brain Sci. 2021 Aug 31;11(9):1162. doi: 10.3390/brainsci11091162.
Binge-eating refers to episodes of uncontrolled eating accompanied by a perceived loss of control, which can be common in the general population. Given the profound negative consequences of persistent binge-eating such as weight and eating disorders, it is vital to determine what makes someone more vulnerable than others to engage in such a conduct. A total of 42 normal-weight individuals (21 with binge-eating episodes and 21 without binge-eating episodes) underwent a structural magnetic resonance imaging measurement and Voxel-based morphometry (VBM) was used to assess between-group differences in terms of gray matter volume (GMV), together with self-report impulsivity and binge-eating measures. The results showed binge-eating individuals as characterized by higher trait impulsivity and greater regional GMV in the left middle frontal gyrus: however, the GMV in this region appeared to be positively correlated only with measures of binge-eating but not with trait impulsivity measures. These findings provide novel insights on the neurobiological roots of BE in normal-weight individuals and highlight how this behavior can be associated with brain morphometric changes within prefrontal regions also in a non-clinical population. Overall, this study provides a further characterization of the neural correlates of binge-eating and novel insights into the treatment of its more severe pathological forms.
暴饮暴食是指在没有控制感的情况下出现的无节制进食，这在普通人群中较为常见。鉴于持续暴饮暴食会带来诸如体重和饮食失调等严重负面后果，确定哪些因素会使某些人比其他人更容易出现这种行为至关重要。共有42名体重正常的个体（21名有暴饮暴食发作史，21名无暴饮暴食发作史）接受了结构磁共振成像测量，并采用基于体素的形态学测量（VBM）来评估两组之间在灰质体积（GMV）方面的差异，同时结合自我报告的冲动性和暴饮暴食测量指标。结果显示，有暴饮暴食行为的个体特征为特质冲动性较高，且左侧额中回的区域GMV更大；然而，该区域的GMV似乎仅与暴饮暴食测量指标呈正相关，与特质冲动性测量指标无关。这些发现为体重正常个体中暴饮暴食的神经生物学根源提供了新的见解，并突出了这种行为在非临床人群中也如何与前额叶区域的脑形态测量变化相关联。总体而言，本研究进一步描述了暴饮暴食的神经关联，并为其更严重病理形式的治疗提供了新的见解。
