Benoit Noémie, Dubois Marie-Julie, Pilon Geneviève, Varin Thibault V, Marette André, Bazinet Laurent
Laboratory of Food Processing and Electromembrane Process (LTAPEM), Department of Food Sciences, Université Laval, Québec, QC G1V 0A6, Canada.
Institute of Nutrition and Functional Foods (INAF), Université Laval, Québec, QC G1V0A6, Canada.
Foods. 2021 Aug 31;10(9):2046. doi: 10.3390/foods10092046.
Over the past years, promising results from studies have shown that herring milt hydrolysates (HMH) can counter immune-metabolic disorders associated with obesity. However, more studies must corroborate these results. Thus, three commercial hydrolysates (HMH1, HMH2, and HMH3) as well as the fractions of two of them (HMH4 and HMH5) obtained by electrodialysis with ultrafiltration membranes (EDUF) were evaluated at higher doses compared to a previous study. To achieve this, seven groups of mice were fed for 8 weeks with either a control Chow diet or an obesogenic diet rich in fat and sucrose (HFHS) and supplemented by daily gavage with water or 312.5 mg/kg of one of the five HMH products. In summary, HMH supplements had no impact on weight gain. In the insulin tolerance test (ITT), HMH2 and its HMH5 fraction significantly reduced the blood sugar variation ( < 0.05). However, during the glucose tolerance (OGTT), HMH2 supplement increased the hyperinsulinemia variation ( < 0.05) induced by the HFHS diet. HMH1, HMH2, and HMH5 supplements generated potentially beneficial changes for health in the gut microbiota. These results reveal that HMH do not counteract obesity effects but may decrease certain physiological effects induced by obesity.
在过去几年中，研究取得的有前景的结果表明，鲱鱼精巢水解物（HMH）可以对抗与肥胖相关的免疫代谢紊乱。然而，更多研究必须证实这些结果。因此，与之前的一项研究相比，对三种商业水解物（HMH1、HMH2和HMH3）以及通过超滤膜电渗析（EDUF）获得的其中两种水解物的组分（HMH4和HMH5）进行了更高剂量的评估。为此，将七组小鼠分别用对照饲料或富含脂肪和蔗糖的致肥胖饮食（HFHS）喂养8周，并通过每日灌胃补充水或五种HMH产品之一，剂量为312.5毫克/千克。总之，HMH补充剂对体重增加没有影响。在胰岛素耐量试验（ITT）中，HMH2及其HMH5组分显著降低了血糖变化（P<0.05）。然而，在葡萄糖耐量试验（OGTT）期间，补充HMH2增加了HFHS饮食诱导的高胰岛素血症变化（P<0.05）。补充HMH1、HMH2和HMH5对肠道微生物群产生了潜在有益的健康变化。这些结果表明，HMH不能抵消肥胖的影响，但可能会降低肥胖诱导的某些生理影响。
