Sugihara Kazunobu, Tanito Masaki
Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.
J Clin Med. 2021 Sep 17;10(18):4202. doi: 10.3390/jcm10184202.
This study aimed to compare intraocular pressures (IOP) using different tonometers, Goldmann applanation (IOP), non-contact (IOP), and rebound (IOP), and to assess the effects of aging and central corneal thickness (CCT) on the measurements. The IOP, IOP, IOP, mean patient age (65.1 ± 16.2 years), and CCT (521.7 ± 39.2 µm) were collected retrospectively from 1054 eyes. The differences among IOPs were compared by the paired -test. Possible correlations between devices, age, and CCT were assessed by linear regression analyses. The effects of age and CCT on the IOP reading were assessed by mixed-effects regression models. The IOP values were 2.4 and 1.4 mmHg higher than IOP and IOP, respectively; the IOP was 1.0 mmHg lower than IOP ( < 0.0001 for all comparisons). The IOPs measured by each tonometer were highly correlated with each other ( = 0.81-0.90, = 45.2-65.5). The linear regression analyses showed that age was negatively correlated with IOP ( = -0.12, = -4.0) and IOP ( = -0.14, = -4.5) but not IOP ( = 0.00, = -0.2); the CCT was positively correlated with IOP ( = 0.13, = 4.3), IOP ( = 0.29, = 9.8), and IOP ( = 0.22, = 7.2). The mixed-effect regression models showed significant negative correlations between age and IOP ( = -2.6) and IOP ( = -3.4), no correlation between age and IOP ( = 0.2), and a significant positive correlation between CCT and the tonometers ( = 3.4-7.3). No differences between IOP and IOP were seen at the age of 38.8 years. CCT affects IOPs from all tonometers; age affects IOP and IOP in different degrees. IOP tended to be higher than IOP in young subjects, but this stabilized in middle age and became higher in older subjects.
本研究旨在比较使用不同眼压计（Goldmann压平眼压计、非接触眼压计和回弹眼压计）测量的眼内压（IOP），并评估年龄和中央角膜厚度（CCT）对测量结果的影响。回顾性收集了1054只眼的Goldmann压平眼压计测量的IOP、非接触眼压计测量的IOP、回弹眼压计测量的IOP、患者平均年龄（65.1±16.2岁）和CCT（521.7±39.2µm）。通过配对t检验比较不同眼压计测量的IOP之间的差异。通过线性回归分析评估不同眼压计测量结果、年龄和CCT之间可能存在的相关性。通过混合效应回归模型评估年龄和CCT对眼压读数的影响。Goldmann压平眼压计测量的IOP值分别比非接触眼压计测量的IOP和回弹眼压计测量的IOP高2.4 mmHg和1.4 mmHg；非接触眼压计测量的IOP比回弹眼压计测量的IOP低1.0 mmHg（所有比较P<0.0001）。每种眼压计测量的IOP之间高度相关（r=0.81 - 0.90，P<45.2 - 65.5）。线性回归分析显示，年龄与Goldmann压平眼压计测量的IOP（r=-0.12，P=-4.0）和非接触眼压计测量的IOP（r=-0.14，P=-4.5）呈负相关，但与回弹眼压计测量的IOP无相关性（r=0.00，P=-0.2）；CCT与Goldmann压平眼压计测量的IOP（r=0.13，P=4.3）、非接触眼压计测量的IOP（r=0.29，P=9.8）和回弹眼压计测量的IOP（r=0.22，P=7.2）呈正相关。混合效应回归模型显示，年龄与Goldmann压平眼压计测量的IOP（P=-2.6）和非接触眼压计测量的IOP（P=-3.4）之间存在显著负相关，年龄与回弹眼压计测量的IOP无相关性（P=0.2），CCT与所有眼压计测量结果之间存在显著正相关（P=3.4 - 7.3）。在38.8岁时，Goldmann压平眼压计测量的IOP和非接触眼压计测量的IOP之间无差异。CCT会影响所有眼压计测量的IOP；年龄对Goldmann压平眼压计测量的IOP和非接触眼压计测量的IOP有不同程度的影响。在年轻受试者中，Goldmann压平眼压计测量的IOP往往高于非接触眼压计测量的IOP，但在中年时这种差异趋于稳定，而在老年受试者中Goldmann压平眼压计测量的IOP更高。
