Vasile Mihaela-Camelia, Arbune Anca-Adriana, Lupasteanu Gabriela, Vlase Constantin-Marinel, Popovici George-Cosmin, Arbune Manuela
The School for Doctoral Studies in Biomedical Sciences, "Dunărea de Jos" University of Galati, 800008 Galati, Romania.
Neurology Clinic, Fundeni Clinical Institute, 022328 Bucharest, Romania.
J Clin Med. 2021 Sep 17;10(18):4210. doi: 10.3390/jcm10184210.
The first cases of COVID-19 were reported in Wuhan Province, in China, in December 2019, spreading rapidly around the world. The World Health Organization (WHO) declared this pandemic at the beginning of March 2020 and, at the same time, the first patient in Galați County was confirmed. Both the global and the regional epidemiological evolutions have taken place with variations in incidence, which have been graphically recorded in several "waves". We conducted a retrospective study on cases of COVID-19 infection, hospitalized between March and June 2020 in an infectious diseases clinic from Galati, in the south-east of Romania. The present paper describes the "first-wave" regional epidemiological and clinical-biological features and the evolution of the COVID-19 pandemic. A poor outcome was related to late presentation to hospital, old age, and over six comorbid conditions including Alzheimer's disease. The high death rate among people from long-term care institutions is the consequence of the cumulative risk factors associated with immune senescence and inflammation, while COVID-19 is more likely a contributing factor to lower life expectancy.
2019年12月，中国湖北省武汉市报告了首批新冠肺炎病例，随后疫情迅速蔓延至全球。2020年3月初，世界卫生组织（WHO）宣布这是一场大流行病，与此同时，加拉茨县的首例患者得到确诊。全球和地区的流行病学演变都伴随着发病率的变化，这些变化已通过图表记录在几个“波峰”中。我们对2020年3月至6月期间在罗马尼亚东南部加拉茨的一家传染病诊所住院的新冠肺炎感染病例进行了回顾性研究。本文描述了“第一波”疫情的地区流行病学、临床生物学特征以及新冠肺炎大流行的演变情况。不良预后与住院延迟、高龄以及包括阿尔茨海默病在内的六种以上合并症有关。长期护理机构人群的高死亡率是与免疫衰老和炎症相关的累积风险因素的结果，而新冠肺炎更可能是导致预期寿命降低的一个促成因素。
