van Wees Christiaan, Rietdijk Wim, Mandigers Loes, van der Graaf Marisa, Scholte Niels T B, Adriaansens Karst O, van den Berg Remco C M, den Uil Corstiaan A
Department of Intensive Care, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Department of Cardiology, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
J Clin Med. 2021 Sep 21;10(18):4286. doi: 10.3390/jcm10184286.
previous studies showed that women have a higher mortality risk than men after out-of-hospital cardiac arrest (OHCA). This sex difference may disappear after adjustment for cardiac arrest characteristics. Most studies also included patients who were not admitted to the intensive care unit (ICU). We analyzed whether sex impacts the mortality of ICU-admitted OHCA patients.
a retrospective cohort analysis of 1240 OHCA patients admitted to the ICU (310 women, 25%, Age 64.0 (IQR 53.8-73.0)) at an academic hospital in the Netherlands between 1 January 2007 and 31 December 2018. The primary outcome was 90-day mortality; the secondary outcome was a favorable cerebral performance category (CPC) score at ICU discharge and ICU length of stay (ICU LOS).
we found no association between sex and 90-day mortality (hazard ratio (HR) 0.867; 95% confidence interval (95% CI) 0.678-1.108) after adjusting for relevant cardiac arrest characteristics. Similarly, we found no difference for favorable CPC score (OR 1.117; 95% CI 0.777-1.608) or ICU LOS between sexes (Beta 0.428; 95% CI -0.442 to 1.298).
after adjusting for cardiac arrest characteristics, we found no difference between women and men with respect to 90-day mortality, ICU LOS, and CPC score.
先前的研究表明，院外心脏骤停（OHCA）后女性的死亡风险高于男性。在对心脏骤停特征进行调整后，这种性别差异可能会消失。大多数研究还纳入了未入住重症监护病房（ICU）的患者。我们分析了性别是否会影响入住ICU的OHCA患者的死亡率。
对2007年1月1日至2018年12月31日期间在荷兰一家学术医院入住ICU的1240例OHCA患者（310例女性，占25%，年龄64.0（四分位间距53.8 - 73.0））进行回顾性队列分析。主要结局是90天死亡率；次要结局是ICU出院时良好的脑功能分类（CPC）评分和ICU住院时间（ICU LOS）。
在对相关心脏骤停特征进行调整后，我们发现性别与90天死亡率之间无关联（风险比（HR）0.867；95%置信区间（95%CI）0.678 - 1.108）。同样，我们发现性别之间在良好的CPC评分（优势比（OR）1.117；95%CI 0.777 - 1.608）或ICU LOS方面无差异（β0.428；95%CI -0.442至1.298）。
在对心脏骤停特征进行调整后，我们发现女性和男性在90天死亡率、ICU LOS和CPC评分方面没有差异。
