成人斯蒂尔病。疾病病程与HLA关联

Adult-onset Still's disease. Disease course and HLA associations.

作者信息

Wouters J M, Reekers P, van de Putte L B

出版信息

Arthritis Rheum. 1986 Mar;29(3):415-8. doi: 10.1002/art.1780290316.

Abstract

Disease course and HLA antigens were determined in 29 patients with definite and 13 patients with probable adult-onset Still's disease (AOSD). Twenty-six patients had persistent disease with continuous disease activity for at least 1 year. Radiographic examination revealed evidence of joint destruction in 26 patients. In 15 patients, at least 1 root joint was impaired. The frequency of DR4 was increased in the total group of patients (35%, P = 0.03) and in the 29 patients with definite AOSD (41%, P = 0.02) compared with the frequency in normal controls (20%). None of the patients was positive for DR1, and only 1 was positive for Bw35. The frequency of DRw6 was increased in the patients with involvement of at least 1 root joint (40%, P = 0.03) compared with the patients without involvement of these joints (11%).

摘要

对29例确诊的和13例可能的成人斯蒂尔病（AOSD）患者的病程和HLA抗原进行了测定。26例患者病情持续，疾病活动至少持续1年。影像学检查显示26例患者有关节破坏的证据。15例患者至少有1个根部关节受损。与正常对照组频率（20%）相比，患者总数中DR4频率增加（35%，P = 0.03），29例确诊AOSD患者中DR4频率增加（41%，P = 0.02）。无一例患者DR1阳性，仅1例Bw35阳性。与未累及这些关节的患者（11%）相比，至少有1个根部关节受累的患者中DRw6频率增加（40%，P = 0.03）。