肠道致病菌的毒力因子：综述。
Virulence Factors of Enteric Pathogenic : A Review.
机构信息
Institute for Life Technologies, University of Applied Sciences Western Switzerland Valais-Wallis, 1950 Sion 2, Switzerland.
Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
出版信息
Int J Mol Sci. 2021 Sep 14;22(18):9922. doi: 10.3390/ijms22189922.
Abstract
are remarkably versatile microorganisms and important members of the normal intestinal microbiota of humans and animals. This harmless commensal organism can acquire a mixture of comprehensive mobile genetic elements that contain genes encoding virulence factors, becoming an emerging human pathogen capable of causing a broad spectrum of intestinal and extraintestinal diseases. Nine definite enteric pathotypes have been well characterized, causing diseases ranging from various gastrointestinal disorders to urinary tract infections. These pathotypes employ many virulence factors and effectors subverting the functions of host cells to mediate their virulence and pathogenesis. This review summarizes new developments in our understanding of diverse virulence factors associated with encoding genes used by different pathotypes of enteric pathogenic to cause intestinal and extraintestinal diseases in humans.
摘要
它们是非常多才多艺的微生物，也是人类和动物正常肠道微生物群的重要成员。这种无害共生体可以获得混合的综合移动遗传元件，其中包含编码毒力因子的基因，从而成为一种新兴的人类病原体，能够引起广泛的肠道和肠道外疾病。已经很好地描述了九个明确的肠病原体，引起的疾病范围从各种胃肠道疾病到尿路感染。这些病原体采用许多毒力因子和效应子来颠覆宿主细胞的功能，以介导它们的毒力和发病机制。本综述总结了我们对不同肠致病性病原体用于引起人类肠道和肠道外疾病的相关编码基因的不同毒力因子的理解的新进展。
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