Foltz Martin, Zahradnik Alicia Christin, Van den Abbeele Pieter, Ghyselinck Jonas, Marzorati Massimo
Döhler GmbH, 64295 Darmstadt, Germany.
Cryptobiotix SA, 9052 Ghent, Belgium.
Microorganisms. 2021 Sep 17;9(9):1981. doi: 10.3390/microorganisms9091981.
Increasing insight into the impact of the gut microbiota on human health has sustained the development of novel prebiotic ingredients. This exploratory study evaluated the prebiotic potential of baobab fruit pulp powder, which consists of pectic polysaccharides with unique composition as compared to other dietary sources, given that it is rich in low methoxylated homogalacturonan (HG). After applying dialysis procedures to remove simple sugars from the product (simulating their absorption along the upper gastrointestinal tract), 48 h fecal batch incubations were performed. Baobab fruit pulp powder boosted colonic acidification across three simulated human adult donors due to the significant stimulation of health-related metabolites acetate (+18.4 mM at 48 h), propionate (+5.5 mM at 48 h), and to a lesser extent butyrate (0.9 mM at 48 h). Further, there was a trend of increased lactate levels (+2.7 mM at 6h) and reduced branched chain fatty acid (bCFA) levels (-0.4 mM at 48 h). While levels increased for all donors, donor-dependent increases in , , and were observed, stressing the potential interindividual differences in microbial composition modulation upon Baobab fruit pulp powder treatment. Overall, Baobab fruit pulp powder fermentation displayed features of selective utilization by host microorganisms and, thus, has promising prebiotic potential (also in comparison with the 'gold standard' prebiotic inulin). Further research will be required to better characterize this prebiotic potential, accounting for the interindividual differences, while aiming to unravel the potential resulting health benefits.
对肠道微生物群对人类健康影响的深入了解推动了新型益生元成分的发展。这项探索性研究评估了猴面包树果肉粉的益生元潜力，与其他膳食来源相比，猴面包树果肉粉由具有独特组成的果胶多糖组成，因为它富含低甲氧基化同型半乳糖醛酸聚糖（HG）。在应用透析程序从产品中去除单糖（模拟它们在上消化道中的吸收）后，进行了48小时的粪便批次培养。由于对与健康相关的代谢产物乙酸盐（48小时时增加18.4 mM）、丙酸盐（48小时时增加5.5 mM）以及程度较轻的丁酸盐（48小时时0.9 mM）有显著刺激作用，猴面包树果肉粉在三名模拟人类成年供体中促进了结肠酸化。此外，乳酸水平有增加的趋势（6小时时增加2.7 mM），支链脂肪酸（bCFA）水平有降低的趋势（48小时时降低0.4 mM）。虽然所有供体的水平都有所增加，但观察到乙酸盐、丙酸盐和丁酸盐的增加存在供体依赖性，强调了猴面包树果肉粉处理后微生物组成调节中潜在的个体差异。总体而言，猴面包树果肉粉发酵显示出被宿主微生物选择性利用的特征，因此具有有前景的益生元潜力（与“金标准”益生元菊粉相比也是如此）。需要进一步的研究来更好地表征这种益生元潜力，考虑个体差异，同时旨在揭示潜在的健康益处。
