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体外果胶发酵对人体粪便微生物群的影响。

The influence of in vitro pectin fermentation on the human fecal microbiome.

作者信息

Bang So-Jung, Kim Gayoung, Lim Mi Young, Song Eun-Ji, Jung Dong-Hyun, Kum Jun-Seok, Nam Young-Do, Park Cheon-Seok, Seo Dong-Ho

机构信息

Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Yongin, 17104, Republic of Korea.

Research Group of Healthcare, Korea Food Research Institute, Wanju, 55365, Republic of Korea.

出版信息

AMB Express. 2018 Jun 16;8(1):98. doi: 10.1186/s13568-018-0629-9.

DOI:10.1186/s13568-018-0629-9
PMID:29909506
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6004267/
Abstract

Pectin is a complex dietary fiber and a prebiotic. To investigate pectin-induced changes in the gut microbiome and their effects on the short chain fatty acids (SCFAs) production, we performed in vitro pectin fermentation using the feces of three Korean donors. The pectin degradations in all three donors were observed. While the donors displayed differences in baseline gut microbiota composition, commonly increased bacteria after pectin fermentation included Lachnospira, Dorea, Clostridium, and Sutterella. Regarding SCFAs, acetate levels rapidly increased with incubation with pectin, and butyrate levels also increased after 6 h of incubation. The results suggest that pectin fermentation increases bacterial species belonging to Clostridium cluster XIV (Lachnospira, Dorea, and Clostridium), with Lachnospira displaying the greatest increase. The results also confirm that pectin fermentation leads to the production of acetate and butyrate.

摘要

果胶是一种复杂的膳食纤维和益生元。为了研究果胶引起的肠道微生物群变化及其对短链脂肪酸（SCFAs）产生的影响，我们使用三名韩国捐赠者的粪便进行了体外果胶发酵实验。观察到所有三名捐赠者的果胶均有降解。虽然捐赠者的基线肠道微生物群组成存在差异，但果胶发酵后普遍增加的细菌包括毛螺菌属、多雷氏菌属、梭菌属和萨特氏菌属。关于短链脂肪酸，与果胶一起孵育后乙酸盐水平迅速增加，孵育6小时后丁酸盐水平也增加。结果表明，果胶发酵增加了属于梭菌属第十四簇（毛螺菌属、多雷氏菌属和梭菌属）的细菌种类，其中毛螺菌属增加最多。结果还证实，果胶发酵会导致乙酸盐和丁酸盐的产生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57da/6004267/f029d93dac04/13568_2018_629_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57da/6004267/9c0cb2b44029/13568_2018_629_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57da/6004267/17e0b971132b/13568_2018_629_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57da/6004267/fc9e4109ac67/13568_2018_629_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57da/6004267/1e483db16da6/13568_2018_629_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57da/6004267/f029d93dac04/13568_2018_629_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57da/6004267/9c0cb2b44029/13568_2018_629_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57da/6004267/17e0b971132b/13568_2018_629_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57da/6004267/fc9e4109ac67/13568_2018_629_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57da/6004267/1e483db16da6/13568_2018_629_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57da/6004267/f029d93dac04/13568_2018_629_Fig5_HTML.jpg

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