Neri-Numa Iramaia Angelica, Pastore Glaucia Maria
Department of Food Science, Faculty of Food Engineering, University of Campinas, Brazil.
Department of Food Science, Faculty of Food Engineering, University of Campinas, Brazil.
Food Res Int. 2020 May;131:108973. doi: 10.1016/j.foodres.2019.108973. Epub 2020 Jan 8.
Dietary prebiotics can be metabolized by different colonic microorganisms and release several classes of metabolites, particularly SCFAs into the intestine lumen, influencing the host physiology. Thus, human microbiota has been the focus of one of the most dynamic research fields of our time and their efforts are directed to understand how prebiotics structures and the microbiota-derived metabolites acts on signaling cell pathways and epigenetic control. Therefore, the aim of this review is to provide an overview about the new concept of prebiotics and their mechanistic local and systemically insights related to the host health.
膳食益生元可被不同的结肠微生物代谢，并向肠腔释放几类代谢产物，尤其是短链脂肪酸，从而影响宿主生理机能。因此，人类微生物群一直是我们这个时代最具活力的研究领域之一，人们致力于了解益生元结构以及微生物群衍生的代谢产物如何作用于细胞信号通路和表观遗传控制。因此，本综述的目的是概述益生元的新概念及其与宿主健康相关的局部和全身作用机制。
