Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 3, 16628 Prague, Czech Republic.
Molecules. 2021 Sep 16;26(18):5627. doi: 10.3390/molecules26185627.
Drug repositioning is a successful approach in medicinal research. It significantly simplifies the long-term process of clinical drug evaluation, since the drug being tested has already been approved for another condition. One example of drug repositioning involves cardiac glycosides (CGs), which have, for a long time, been used in heart medicine. Moreover, it has been known for decades that CGs also have great potential in cancer treatment and, thus, many clinical trials now evaluate their anticancer potential. Interestingly, heart failure and cancer are not the only conditions for which CGs could be effectively used. In recent years, the antiviral potential of CGs has been extensively studied, and with the ongoing SARS-CoV-2 pandemic, this interest in CGs has increased even more. Therefore, here, we present CGs as potent and promising antiviral compounds, which can interfere with almost any steps of the viral life cycle, except for the viral attachment to a host cell. In this review article, we summarize the reported data on this hot topic and discuss the mechanisms of antiviral action of CGs, with reference to the particular viral life cycle phase they interfere with.
药物重定位是医学研究中一种成功的方法。由于被测试的药物已经被批准用于另一种疾病，因此大大简化了长期的临床药物评估过程。药物重定位的一个例子是强心苷（CGs），它们长期以来一直用于心脏病药物。此外，几十年来，人们已经知道 CGs 在癌症治疗方面也具有巨大的潜力，因此，许多临床试验现在正在评估它们的抗癌潜力。有趣的是，心力衰竭和癌症并不是 CGs 可以有效使用的唯一疾病。近年来，CGs 的抗病毒潜力已得到广泛研究，随着当前 SARS-CoV-2 大流行，人们对 CGs 的兴趣更加浓厚。因此，在这里，我们将 CGs 作为有效的、有前途的抗病毒化合物进行介绍，这些化合物几乎可以干扰病毒生命周期的任何步骤，除了病毒与宿主细胞的附着。在这篇综述文章中，我们总结了关于这个热门话题的报道数据，并讨论了 CGs 的抗病毒作用机制，参考了它们干扰的特定病毒生命周期阶段。
