Bartfeld H, Pollack M S, Cunningham-Rundles S, Donnenfeld H
Arch Neurol. 1982 May;39(5):270-1. doi: 10.1001/archneur.1982.00510170012003.
Our study of the distribution of HLA-A, -B, and -C in patients with amyotrophic lateral sclerosis (ALS) found no statistically significant deviation. We found a trend, however, toward a decrease in HLA-A9, as we had reported previously, and toward an increase in HLA-Bw35 and -Cw4. The worldwide incidence of ALS is uniform except in Guam and on Japan's Kii peninsula, and published reports from many countries, including Guam, show no consistent deviation in HLA frequencies related to ALS.
我们对肌萎缩侧索硬化症（ALS）患者中HLA - A、- B和 - C分布的研究发现，在统计学上没有显著偏差。然而，正如我们之前所报道的，我们发现HLA - A9有下降趋势，而HLA - Bw35和 - Cw4有上升趋势。除了关岛和日本的纪伊半岛外，ALS在全球的发病率是一致的，包括关岛在内的许多国家发表的报告显示，与ALS相关的HLA频率没有一致的偏差。
