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果糖代谢与青少年和青年的代谢功能障碍。

Fructose Metabolism and Metabolic Dysfunction in Adolescents and Young Adults.

机构信息

Division of Gastroenterology, Hepatology, Nutrition, Department of Pediatrics, University of Kentucky College of Medicine and Kentucky Children's Hospital, Lexington, KY 40536, USA.

Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40506, USA.

出版信息

Nutrients. 2023 Jul 16;15(14):3162. doi: 10.3390/nu15143162.

DOI:10.3390/nu15143162
PMID:37513580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10383708/
Abstract

There is a worldwide epidemic of obesity and its associated metabolic dysfunction [...].

摘要

目前肥胖及其相关代谢功能紊乱在全球流行。

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Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.果糖诱导的 KHK-C 可以增加 ER 应激，而不依赖于其对脂肪生成的影响，从而在饮食诱导和 NAFLD 的遗传模型中驱动肝脏疾病。
Metabolism. 2023 Aug;145:155591. doi: 10.1016/j.metabol.2023.155591. Epub 2023 May 23.
2
Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation.酮己激酶-C 调节全局蛋白质乙酰化，以降低肉毒碱棕榈酰基转移酶 1a 介导的脂肪酸氧化。
J Hepatol. 2023 Jul;79(1):25-42. doi: 10.1016/j.jhep.2023.02.010. Epub 2023 Feb 21.
3
Fructose impairs fat oxidation: Implications for the mechanism of western diet-induced NAFLD.果糖会损害脂肪氧化：这对西式饮食导致非酒精性脂肪肝的发病机制有影响。
J Nutr Biochem. 2023 Apr;114:109224. doi: 10.1016/j.jnutbio.2022.109224. Epub 2022 Nov 18.
4
The Dose-Response Effects of Consuming High Fructose Corn Syrup-Sweetened Beverages on Hepatic Lipid Content and Insulin Sensitivity in Young Adults.年轻人摄入高果糖玉米糖浆饮料对肝内脂质含量和胰岛素敏感性的剂量反应影响。
Nutrients. 2022 Apr 15;14(8):1648. doi: 10.3390/nu14081648.
5
Dietary Counseling Aimed at Reducing Sugar Intake Yields the Greatest Improvement in Management of Weight and Metabolic Dysfunction in Children with Obesity.饮食咨询旨在减少糖摄入量，可最大程度改善肥胖儿童的体重和代谢功能障碍管理。
Nutrients. 2022 Apr 3;14(7):1500. doi: 10.3390/nu14071500.
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The Impact of Gut Microbiome on Maternal Fructose Intake-Induced Developmental Programming of Adult Disease.肠道微生物组对母体果糖摄入诱导的成年疾病发育编程的影响。
Nutrients. 2022 Feb 28;14(5):1031. doi: 10.3390/nu14051031.
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A Systems Approach Dissociates Fructose-Induced Liver Triglyceride from Hypertriglyceridemia and Hyperinsulinemia in Male Mice.系统方法将果糖诱导的肝甘油三酯与雄性小鼠的高甘油三酯血症和高胰岛素血症分离。
Nutrients. 2021 Oct 18;13(10):3642. doi: 10.3390/nu13103642.
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Pediatr Obes. 2022 Mar;17(3):e12862. doi: 10.1111/ijpo.12862. Epub 2021 Oct 18.
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