Adegbite Ayobami, McCarthy Pumtiwitt C
Bioenvironmental Sciences Program, Morgan State University, Baltimore, MD 21251, USA.
Department of Chemistry, Morgan State University, Baltimore, MD 21251, USA.
Vaccines (Basel). 2021 Sep 14;9(9):1021. doi: 10.3390/vaccines9091021.
Vaccines are important in preventing disease outbreaks and controlling the spread of disease in a population. A variety of vaccines exist, including subunit, recombinant, and conjugate vaccines. Glycoconjugate vaccines have been an important tool to fight against diseases caused by a number of bacteria. Glycoconjugate vaccines are often heterogeneous. Vaccines of the future are becoming more rationally designed to have a defined oligosaccharide chain length and position of conjugation. Homogenous vaccines could play an important role in assessing the relationship between vaccine structure and immune response. This review focuses on recent advances in the chemoenzymatic production of defined bacterial oligosaccharides for vaccine development with a focus on and selected WHO-prioritized antibacterial resistant-pathogens. We also provide some perspective on future advances in the chemoenzymatic synthesis of well-defined oligosaccharides.
疫苗对于预防疾病爆发和控制疾病在人群中的传播至关重要。现有多种疫苗，包括亚单位疫苗、重组疫苗和结合疫苗。糖结合疫苗一直是对抗多种细菌引起的疾病的重要工具。糖结合疫苗通常是异质的。未来的疫苗正变得更加合理设计，以具有确定的寡糖链长度和结合位置。均质疫苗在评估疫苗结构与免疫反应之间的关系方面可能发挥重要作用。本综述重点关注用于疫苗开发的特定细菌寡糖的化学酶法生产的最新进展，重点关注世界卫生组织优先列出的抗菌耐药病原体。我们还对明确寡糖的化学酶法合成的未来进展提供了一些展望。
