咖啡饮用与结直肠癌风险。

Coffee consumption and risk of colorectal cancer.

机构信息

Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

出版信息

Eur J Clin Nutr. 2010 Sep;64(9):917-23. doi: 10.1038/ejcn.2010.103. Epub 2010 Jun 23.

DOI:10.1038/ejcn.2010.103

PMID:20571499

Abstract

BACKGROUND/OBJECTIVES: The possible association between coffee consumption and risk of colorectal cancer has been extensively studied in the many populations. The aim of this study is to examine this relationship among Finns, who are the heaviest coffee consumers in the world.

SUBJECTS/METHODS: A total of 60 041 Finnish men and women who were 26-74 years of age and without history of any cancer at baseline were included in the present analyses. Their coffee consumption and other study characteristics were determined at baseline, and they were prospectively followed up for onset of colon and rectal cancer, emigration, death or until 30 June 2006.

RESULTS

During a mean follow-up period of 18 years, 538 cases of colorectal cancer (304 cases of colon cancer and 234 cases of rectal cancer) were diagnosed. The multivariate-adjusted hazard ratio of colorectal cancer incidence for > or =10 cups of coffee per day compared with non-drinkers was 0.98 (95% CI, 0.47-2.03) for men (P for trend=0.86), 1.24 (95% CI, 0.49-3.14) for women (p for trend=0.83) and 1.03 (95% CI, 0.58-1.83) for men and women combined (P for trend=0.61).

CONCLUSIONS

In this study, we found no association between coffee consumption and the risk of colorectal, colon and rectal cancer.

摘要

背景/目的：咖啡消费与结直肠癌风险之间的可能关联已在许多人群中进行了广泛研究。本研究旨在检查世界上咖啡消费最多的芬兰人群中的这种关系。

对象/方法：本研究共纳入 60041 名年龄在 26-74 岁之间、基线时无任何癌症史的芬兰男性和女性。在基线时确定了他们的咖啡消费和其他研究特征，并对他们进行了前瞻性随访，以了解结肠癌和直肠癌的发病情况、移民、死亡或直至 2006 年 6 月 30 日。

结果

在平均 18 年的随访期间，诊断出 538 例结直肠癌（304 例结肠癌和 234 例直肠癌）。与不饮用者相比，每天饮用>或=10 杯咖啡的男性（趋势检验 P=0.86）、女性（趋势检验 P=0.83）和男女合计（趋势检验 P=0.61）患结直肠癌、结肠癌和直肠癌的风险的多变量调整后的危险比分别为 0.98（95%CI，0.47-2.03）、1.24（95%CI，0.49-3.14）和 1.03（95%CI，0.58-1.83）。