一例红白血病中的均匀染色染色体区域。

Homogeneously staining chromosomal region in a case of erythroleukaemia.

作者信息

Kovacs G, Freund M, Poliwoda H, Leithauser H, Thiel E

出版信息

Scand J Haematol. 1986 Feb;36(2):232-7. doi: 10.1111/j.1600-0609.1986.tb00834.x.

DOI:10.1111/j.1600-0609.1986.tb00834.x

Abstract

Cytogenetical analysis of bone marrow and peripheral blood cells in a case of erythroleukaemia revealed a complex karyotype with a stemline of 44 chromosomes. 1 marker chromosome bearing a homogeneously staining region (hsr) was found in each of the aneuploid cells examined. The hsr was localised to the chromosome regions 15q12 and 15p12. The possible function of amplified DNA sequences and the relationship of hsr to cell proliferation are discussed.

摘要

对一例红白血病患者的骨髓和外周血细胞进行细胞遗传学分析，结果显示其核型复杂，主干线为44条染色体。在所检查的每个非整倍体细胞中均发现了1条带有均匀染色区（hsr）的标记染色体。该均匀染色区定位于染色体区域15q12和15p12。文中讨论了扩增DNA序列的可能功能以及均匀染色区与细胞增殖的关系。