Enomoto Nao, Nakamura Sho, Kanda Satoru, Endo Hiroko, Yamada Emiko, Kobayashi Sachiyo, Kido Miki, Inoue Rina, Shimakura Junko, Narimatsu Hiroto
Section of Health and Longevity Service, Takahata Town Office, Takahata, Yamagata, Japan.
Graduate School of Health of Innovation, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan.
Risk Manag Healthc Policy. 2021 Sep 21;14:3935-3943. doi: 10.2147/RMHP.S323444. eCollection 2021.
A tailored approach to individual risk factors for developing lifestyle-related diseases would help induce behavioral changes toward intervention acceptability. The addition of preventive healthcare programs to nationwide specific health guidance in Japan is adapted in a given region.
We conducted a prospective parallel-group comparison study on 195 eligible residents from Takahata, Japan, with a high risk of lifestyle-related diseases from 2014 to 2017 to examine whether such an intervention could improve the body mass index (BMI) and estimated glomerular filtration rate (eGFR).
Of the 195 enrolled residents, 117 were assigned to the control group and 78 to the intervention group. They were ≤65 years old and had a BMI ≥25 kg/m and an eGFR ≤90 mL/kg/1.73 m. We conducted certain interventions for each group, including additional blood testing, regular health guidance, and specific health guidance. After one year, neither BMI (intervention: 26.7 ± 2.17 kg/m vs control: 27.3 ± 2.12 kg/m, p = 0.076) nor eGFR (intervention: 72.2 ± 11.1 mL/kg/1.73 m vs control: 73.1 ± 10.5 mL/kg/1.73 m, p = 0.608) differed significantly between groups. However, after three years, the BMI in the intervention group (26.4 ± 2.05 kg/m) was significantly reduced compared to that in the control group (27.4 ± 2.26 kg/m; p = 0.005).
The additional interventions might have contributed to a reduction in metabolic syndrome.
This study was registered in the UMIN-Clinical Trials Registry (ID:000013581). More information: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000015868. The registration date was 31/03/2014.
针对与生活方式相关疾病的个体风险因素采取量身定制的方法，将有助于促使行为改变，提高干预的可接受性。在日本，将预防性医疗保健项目添加到全国性的特定健康指导中，并在特定地区实施。
2014年至2017年，我们对日本高幡的195名符合条件的居民进行了一项前瞻性平行组比较研究，这些居民患有与生活方式相关疾病的风险较高，以检验这种干预措施是否能改善体重指数（BMI）和估计肾小球滤过率（eGFR）。
在195名登记居民中，117人被分配到对照组，78人被分配到干预组。他们年龄≤65岁，BMI≥25kg/m，eGFR≤90mL/kg/1.73m²。我们对每组进行了某些干预，包括额外的血液检测、定期健康指导和特定健康指导。一年后，两组之间的BMI（干预组：26.7±2.17kg/m²，对照组：27.3±2.12kg/m²，p=0.076）和eGFR（干预组：72.2±11.1mL/kg/1.73m²，对照组：73.1±10.5mL/kg/1.73m²，p=0.608）均无显著差异。然而，三年后，干预组的BMI（26.4±2.05kg/m²）与对照组（27.4±2.26kg/m²；p=0.005）相比显著降低。
额外的干预措施可能有助于降低代谢综合征的发生率。
本研究已在UMIN临床试验注册中心注册（编号：000013581）。更多信息：https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000015868。注册日期为2014年3月31日。
