Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Gut Microbes. 2021 Jan-Dec;13(1):1974795. doi: 10.1080/19490976.2021.1974795.
An imbalance in the crosstalk between the host and gut microbiota affects the intestinal barrier function, which results in inflammatory diseases and colorectal cancer. The colon epithelium protects itself from a harsh environment and various pathogenic organisms by forming a double mucus layer, primarily comprising mucins. Recent studies are focusing on how dietary patterns alter the gut microbiota composition, which in turn regulates mucin expression and maintains the intestinal layers. In addition, modulation of gut microbiota by microbiotic therapy (involving fecal microbiota transplantation) has emerged as a significant factor in the pathologies associated with dysbiosis. Therefore, proper communication between host and gut microbiota different dietary patterns (prebiotics and probiotics) is needed to maintain mucus composition, mucin synthesis, and regulation. Here, we review how the interactions between diet and gut microbiota and bacterial metabolites () regulate mucus layer functionalities and mucin expression in human health and disease.
肠道菌群与宿主之间的相互作用失衡会影响肠道屏障功能，从而导致炎症性疾病和结直肠癌。结肠上皮通过形成双层黏液层来保护自己免受恶劣环境和各种病原微生物的侵害，主要由黏蛋白组成。最近的研究集中在饮食模式如何改变肠道菌群组成，进而调节黏蛋白表达并维持肠道层。此外，通过微生物治疗（包括粪便微生物移植）来调节肠道菌群已成为与菌群失调相关病理的重要因素。因此，需要宿主与肠道菌群之间的适当交流，以及不同的饮食模式（益生元和益生菌）来维持黏液组成、黏蛋白合成和调节。在这里，我们综述了饮食和肠道菌群以及细菌代谢物（）之间的相互作用如何调节人类健康和疾病中的黏液层功能和黏蛋白表达。
