C.G. Bhakta Institute of Biotechnology, Uka Tarsadia University, Gopal-Vidyanagar, Maliba Campus, Surat, Gujarat 394350, India.
Uka Tarsadia University.
Crit Rev Ther Drug Carrier Syst. 2025;42(1):89-118. doi: 10.1615/CritRevTherDrugCarrierSyst.v42.i1.30.
Cancer is one of the major life-threatening diseases in the world and oral cancer is the 8th most common type of deadly cancers in Asian countries. Despite many causes, tobacco is the main causative agent as 90% of oral cancer cases were due to daily consumption of tobacco and its products. The major drawback of the conventional therapies for oral cancer including chemotherapy, surgery and radiotherapy or combination of these is the dose limiting toxicity. Developments in technology and research led to new innovative discoveries in cancer treatments. In the past few decades, increased attention has been given to researches in alternative cancer treatment strategies using plants and plant products. Recently many anticancer drugs from natural products or phytochemicals were approved internationally. Due to the low bioavailability and poor solubility of phytochemicals, various research works on nano-carrier based drug delivery systems were exploited in the recent past to make them as promising anticancer agents. In the current review, an overview of oral cancer and its treatment, risk factors, missing links of conventional therapies, contribution of nanotechnology in cancer treatment and research on phytochemical based drug treatment and different polymeric nanoparticles were discussed briefly. The future prospects for the use of various types of polymeric nanoparticles applied in the diagnosis and treatment of oral cancer were also mentioned. The major concern of this review is to give the reader a better understanding on various types of treatment for oral cancer.
癌症是全球主要的危及生命的疾病之一，口腔癌是亚洲国家中第 8 种最常见的致命癌症。尽管有许多病因，但烟草是主要的致病因素，因为 90%的口腔癌病例是由于日常消费烟草及其制品所致。包括化疗、手术和放疗或这些方法的联合应用在内的传统口腔癌治疗方法的主要缺点是剂量限制毒性。技术和研究的发展导致了癌症治疗方面新的创新发现。在过去几十年中，人们越来越关注使用植物和植物产品的替代癌症治疗策略的研究。最近，许多来自天然产物或植物化学物质的抗癌药物在国际上获得批准。由于植物化学物质的生物利用度低和溶解度差，最近的研究工作主要集中在基于纳米载体的药物传递系统上，以使其成为有前途的抗癌药物。在目前的综述中，简要概述了口腔癌及其治疗、危险因素、传统疗法的缺失环节、纳米技术在癌症治疗中的贡献以及基于植物化学物质的药物治疗和不同聚合物纳米粒子的研究。还提到了在口腔癌的诊断和治疗中应用各种类型聚合物纳米粒子的未来前景。本篇综述的主要关注点是让读者更好地了解口腔癌的各种治疗方法。
