Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Department of Chemistry, Maulana Azad National Institute of Technology, Bhopal, 462003, MP, India.
Drug Des Devel Ther. 2021 Sep 23;15:4043-4052. doi: 10.2147/DDDT.S322769. eCollection 2021.
Synergy is defined as an interaction of some substances that cooperate to give rise to the combined effect greater than the sum of their individual effects. It is a natural strategy that has evolved by nature to more efficacy with low cost.
This study is designed to evaluate the chemopreventive effect of a combined drug sample which is prepared by mixing an equal portion of stigmasterol and palmatine isolated from and respectively at a concentration of 100 mg/kg and 200 mg/kg body weight during the whole concentration.
At the end of the study, it was found that this combined drug sample decreased the number of tumors and their size. This drug significantly reduced the serum level of glutamate pyruvate transaminase, alkaline phosphatase, glutamate oxalate transaminase, and bilirubin and enhanced the level of oxidative enzyme level of glutathione, superoxide dismutase, and catalase, and inhibit the level of lipid peroxides.
The result suggests that combined drug samples exhibit a chemopreventive effect which is better than the effect of individual drugs (stigmasterol and palmatine).
协同作用被定义为某些物质的相互作用，它们共同产生的联合效应大于它们各自效应的总和。这是一种自然策略，是为了以低成本实现更高的功效而进化而来的。
本研究旨在评估一种联合药物样本的化学预防作用，该药物样本是通过将从 和 中分离得到的等量豆甾醇和黄连碱混合而成，浓度为 100mg/kg 和 200mg/kg 体重。
研究结束时，发现该联合药物样本减少了肿瘤数量及其大小。该药物显著降低了血清谷氨酸丙酮酸转氨酶、碱性磷酸酶、谷氨酸草酰转氨酶和胆红素的水平，同时提高了谷胱甘肽、超氧化物歧化酶和过氧化氢酶的氧化酶水平，并抑制了脂质过氧化物的水平。
结果表明，联合药物样本表现出的化学预防作用优于单独药物（豆甾醇和黄连碱）的作用。
