Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Department of Oncology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Bioengineered. 2021 Dec;12(1):7263-7275. doi: 10.1080/21655979.2021.1976897.
Asymptomatic hyperuricemia (AH) is an early stage of gout. Emerging evidence shows that the intestinal microbiota is related to gout. However, the relationship between AH and the intestinal microbiota is poorly understood. Therefore, the aim of the current study was to explore the possible correlation between AH and intestinal flora. We compared the intestinal microbial communities of AH (45 cases) and healthy subjects (45 cases) by 16S rRNA gene sequencing and clustering analysis on the incorporated population. Intestinal-type clustering can be divided into two groups, and significant differences in the proportion of AH are found among different bowel types. Alpha diversity indices were higher in the AH group than in the control group, and beta diversity indices also showed significant differences. A total of 19 genera were found different between the AH group and the control group. Compared with the control group, some probiotics are increased in the AH population. Two groups were ranked by importance of bacteria. We found the different bacteria partially coincided with the important bacteria, and the joint diagnosis level of the important bacteria was good. Conclusion: There were significant differences in the composition of intestinal biota between AH patients and healthy subjects. Some probiotics increased in AH.
无症状高尿酸血症 (AH) 是痛风的早期阶段。新出现的证据表明，肠道微生物群与痛风有关。然而，AH 与肠道微生物群之间的关系尚不清楚。因此，本研究旨在探讨 AH 与肠道菌群之间可能存在的相关性。我们通过 16S rRNA 基因测序和整合人群聚类分析比较了 AH（45 例）和健康受试者（45 例）的肠道微生物群落。肠道型聚类可分为两组，不同肠道类型的 AH 比例存在显著差异。AH 组的 alpha 多样性指数高于对照组，beta 多样性指数也有显著差异。在 AH 组和对照组之间共发现 19 个属存在差异。与对照组相比，AH 人群中某些益生菌增加。两组按细菌重要性进行排序。我们发现不同的细菌与重要细菌部分吻合，重要细菌的联合诊断水平较好。结论：AH 患者和健康受试者的肠道菌群组成存在显著差异。AH 中某些益生菌增加。
