Department of Ophthalmology, the First Hospital of China Medical University, Shenyang, Liaoning, China.
Department of Cardiology, the First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, China.
BMC Public Health. 2021 Apr 23;21(1):776. doi: 10.1186/s12889-021-10858-x.
To investigate the combined effect of hypertension and hyperuricemia to the risk of ischemic stroke in a rural Chinese population.
The cross-sectional study was conducted from 2012 to 2013 in a rural area of China. After exclusion for missing data, we finally included 11,731 participants into analysis.
After adjusting for age, current smoking, current drinking, BMI, TG, HDL-C and eGFR, hypertension was significantly associated with ischemic stroke in men (OR: 2.783, 95% CI: 1.793, 4.320) and in women (OR: 4.800, 95% CI: 2.945, 7.822). However, hyperuricemia was significantly associated with ischemic stroke only in women (OR: 1.888, 95% CI: 1.244, 2.864). After full adjustment, participants with both hypertension and hyperuricemia had 8.9 times higher risk than those without them. Finally, the interaction between hypertension and hyperuricemia was statistically significant only in women rather than in men after full adjustment.
This study demonstrated the positive correlations between hypertension, hyperuricemia and ischemic stroke. Our study also demonstrated the joint effect between hypertension and hyperuricemia towards ischemic stroke only in women, not in men.
本研究旨在探讨中国农村人群中高血压和高尿酸血症联合对缺血性脑卒中发病风险的影响。
本横断面研究于 2012 年至 2013 年在中国农村地区进行。排除缺失数据后，最终纳入 11731 名参与者进行分析。
校正年龄、当前吸烟、当前饮酒、BMI、TG、HDL-C 和 eGFR 后，高血压与男性（OR：2.783，95%CI：1.793，4.320）和女性（OR：4.800，95%CI：2.945，7.822）缺血性脑卒中发病风险显著相关。然而，高尿酸血症仅与女性缺血性脑卒中发病风险显著相关（OR：1.888，95%CI：1.244，2.864）。校正后，高血压和高尿酸血症并存的患者缺血性脑卒中发病风险是无高血压和高尿酸血症患者的 8.9 倍。校正后，高血压和高尿酸血症对缺血性脑卒中发病风险的联合作用仅在女性中具有统计学意义，而在男性中则无统计学意义。
本研究表明高血压、高尿酸血症与缺血性脑卒中之间存在正相关关系。本研究还表明，高血压和高尿酸血症对缺血性脑卒中的联合作用仅在女性中存在，而在男性中则不存在。
