Influence of Short-Term Consumption of on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study.

() is widely studied as a medicinal and edible fungus. Recent studies have shown that has protective effects for diseases, such as inflammatory bowel disease and cancer, which are related to gut microbiota. To investigate the benefits of intake on gut microbiota and blood indices in adulthood, we recruited 13 healthy adults to consume powder as a dietary supplement. Blood changes due to consumption were determined by routine hematological examination and characterized by serum biochemical markers. Microbiota composition was profiled by 16S ribosomal RNA gene sequencing. Results showed that daily supplementation increased the alpha diversity within the gut microbiota community, upregulated the relative abundance of some short-chain fatty acid (SCFA) producing bacteria (, , , , ), and downregulated some pathobionts (, , ). Changes within the gut microbiota were correlated with blood chemical indices including alkaline phosphatase (ALP), low-density lipoprotein (LDL), uric acid (UA), and creatinine (CREA). Thus, we found that the gut microbiota alterations may be part of physiological adaptations to a seven-day supplementation, potentially influencing beneficial health effects.