Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
J Mycol Med. 2022 Mar;32(1):101207. doi: 10.1016/j.mycmed.2021.101207. Epub 2021 Sep 22.
Talaromyces marneffei is one of the endemic mycoses prevalent in South-East Asian region. The infection, which was once considered to be opportunistic infection in HIV-positive patients, is establishing foothold in transplant and immunocompetent population. We report a case of a 41-year-old post-renal transplant female with a travel history to Assam two years back presenting with a subcutaneous lesion on right side of scalp associated with pain and blurring of vision in right eye. Fine-needle aspiration from the scalp lesion showed yeast cells with transverse septation in cytological examination and culture grew Talaromyces marneffei, which was confirmed by sequencing of ITS region. Patient was successfully managed with oral itraconazole 200 mg twice daily for ten months without subsequent recurrence. To our knowledge, this is the first case of subcutaneous infection by T. marneffei in a renal transplant recipient from India.
马尔尼菲青霉是东南亚地区流行的地方性真菌病之一。这种感染曾经被认为是 HIV 阳性患者的机会性感染，但现在已在移植和免疫功能正常的人群中立足。我们报告了一例 41 岁的女性肾移植后患者，两年前曾前往阿萨姆邦旅行，现右侧头皮有一处皮下病变，伴有右眼疼痛和视力模糊。头皮病变的细针抽吸显示细胞学检查中有具横隔的酵母细胞，且培养出了马尔尼菲青霉，ITS 区测序结果也证实了这一点。患者成功地接受了每日两次口服伊曲康唑 200 毫克治疗十个月，没有后续复发。据我们所知，这是首例来自印度的肾移植受者发生马尔尼菲青霉皮下感染的病例。
