Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Trends Pharmacol Sci. 2021 Nov;42(11):883-896. doi: 10.1016/j.tips.2021.09.001. Epub 2021 Sep 28.
Minimally invasive focal therapies for nonviral oncolysis are a cornerstone of cancer therapeutics. Our ability to optimally deploy oncolytic therapies and identify synergistic combination approaches requires a deeper understanding of elicited biological responses. Extracellular vesicles (EV), which orchestrate a variety of pathophysiological processes and have a critical role in the evolution of primary and disseminated tumors, are now known to be potently modulated by oncolytic focal therapies, such as radiotherapy, photodynamic therapy (PDT), and therapeutic ultrasound (TUS). In this review, we summarize the diverse impacts of the aforementioned therapeutic modalities on EV biology, and highlight the most recent advances in EV-based drug delivery systems leveraging these modalities.
微创的非病毒肿瘤溶解局部治疗是非病毒肿瘤溶解的基石。为了优化肿瘤溶解疗法的应用并确定协同联合方法，我们需要更深入地了解所引起的生物学反应。细胞外囊泡（EV）可以协调多种病理生理过程，在原发性和播散性肿瘤的发展中起着关键作用，现在已知可以被肿瘤溶解的局部治疗方式（如放射疗法、光动力疗法（PDT）和治疗性超声（TUS））强烈调节。在这篇综述中，我们总结了上述治疗方法对 EV 生物学的多种影响，并强调了利用这些方法的基于 EV 的药物传递系统的最新进展。
