骨肉瘤中外泌体的功能及治疗潜力
Functions and therapeutic potentials of exosomes in osteosarcoma.
作者信息
Yue Jiaji, Chen Zhe-Sheng, Xu Xiang-Xi, Li Shenglong
机构信息
Department of Bone and Joint Surgery, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, 518000, PR China.
College of Pharmacy and Health Sciences, St. John's University, Queens, NY,United States.
出版信息
Acta Mater Med. 2022 Oct 18;1(4):552-562. doi: 10.15212/amm-2022-0024. Epub 2022 Dec 30.
Abstract
Osteosarcoma is a primary malignant tumor of the skeleton with the morbidity of 2.5 in 1 million. The regularly on-set is in the epiphysis of the extremities with a high possibility of early metastasis, rapid progression, and poor prognosis. The survival rate of patients with metastatic or recurrent osteosarcoma remains low, and novel diagnostic and therapeutic methods are urgently needed. Exosomes are extracellular vesicles 30-150 nm in diameter secreted by various cells that are widely present in various body fluids. Exosomes are abundant in biologically active components such as proteins, nucleic acids, and lipids. Exosomes participate in numerous physiological and pathological processes via intercellular substance exchange and signaling. This review presents the novel findings of exosomes in osteosarcoma in diagnosis, prognosis, and therapeutic aspects.
摘要
骨肉瘤是一种原发性骨骼恶性肿瘤，发病率为百万分之2.5。其发病部位通常在四肢骨骺，早期转移可能性高，进展迅速，预后较差。转移性或复发性骨肉瘤患者的生存率仍然很低，迫切需要新的诊断和治疗方法。外泌体是直径为30 - 150纳米的细胞外囊泡，由各种细胞分泌，广泛存在于各种体液中。外泌体富含蛋白质、核酸和脂质等生物活性成分。外泌体通过细胞间物质交换和信号传导参与众多生理和病理过程。本文综述了外泌体在骨肉瘤诊断、预后和治疗方面的新发现。
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