Departamento de Medicina Clínica, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.
Internal Medicine Department, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil.
Vaccine. 2021 Oct 22;39(44):6454-6459. doi: 10.1016/j.vaccine.2021.09.057. Epub 2021 Sep 25.
To identify potential predictors of COVID-19 vaccine hesitancy (C19-VH) in adults with immune-mediated inflammatory diseases (IMID).
A total of 1000 IMID patients were enrolled in this web-based cross-sectional study. A standardised and self-administered survey was designed by members of the Brazilian Society of Rheumatology Steering Committee for Infectious and Endemic diseases and distributed to IMID patients spread across Brazil.
Of the 908 (90.8%) respondents eligible for analysis, 744 (81.9%) were willing to get vaccinated against COVID-19. In our multivariable logistic regression model, concurrent malignancy, fibromyalgia, hydroxychloroquine use, and recent corticosteroid pulse therapy were independently associated with higher odds of C19-VH. The short duration of COVID-19 vaccine clinical trials was the main reason for C19-VH.
We identified novel characteristics potentially associated with C19-VH among adults with IMID. Greater awareness on the safety and efficacy of COVID-19 vaccines is needed for both IMID patients and attending physicians.
确定免疫介导的炎症性疾病（IMID）成人对 COVID-19 疫苗犹豫不决（C19-VH）的潜在预测因素。
本项基于网络的横断面研究共纳入了 1000 名 IMID 患者。由巴西风湿病学会传染病和地方病指导委员会成员设计了一份标准化的自我管理调查问卷，并分发给分布在巴西各地的 IMID 患者。
在符合分析条件的 908 名（90.8%）应答者中，744 名（81.9%）愿意接种 COVID-19 疫苗。在我们的多变量逻辑回归模型中，同时患有恶性肿瘤、纤维肌痛、羟氯喹的使用以及最近接受皮质类固醇脉冲治疗与更高的 C19-VH 几率相关。COVID-19 疫苗临床试验的持续时间短是 C19-VH 的主要原因。
我们发现了成年人免疫介导的炎症性疾病与 C19-VH 相关的新特征。需要提高 IMID 患者和主治医生对 COVID-19 疫苗的安全性和有效性的认识。
