Liu Weijian, Gu Hua, Ran Bei, Liu Wenkai, Sun Wen, Wang Dongping, Du Jianjun, Fan Jiangli, Peng Xiaojun
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024 China.
Ningbo Institute of Dalian University of Technology, Ningbo, 315016 China.
Sci China Mater. 2022;65(3):845-854. doi: 10.1007/s40843-021-1770-0. Epub 2021 Sep 23.
The emergence of antibiotic resistance in bacteria is a major public-health issue. Synthesis of efficient antibiotic-free material is very important for fighting bacterial infection-related diseases. Herein, red-carbon dots (R-CDs) with a broad range of spectral absorption (350-700 nm) from organic bactericides or intermediates were synthesized through a solvothermal route. The prepared R-CDs not only had intrinsic antibacterial activities, but also could kill multidrug-resistant bacteria (multidrug-resistant (MRAB) and multidrug-resistant (MRSA)) effectively by generating reactive oxygen species. Furthermore, R-CDs could eliminate and inhibit the formation of MRAB biofilms, while conferring few side effects on normal cells. A unique property of R-CDs was demonstrated upon treatment of antibiotic-sensitive MRAB-induced infected wounds. These data suggested that this novel R-CDs-based strategy might enable the design of next-generation agents to fight drug-resistant bacteria.
Supplementary material is available for this article at 10.1007/s40843-021-1770-0 and is accessible for authorized users.
细菌中抗生素耐药性的出现是一个重大的公共卫生问题。合成高效的无抗生素材料对于对抗细菌感染相关疾病非常重要。在此，通过溶剂热法合成了具有广泛光谱吸收范围（350 - 700 nm）的红色碳点（R - CDs），其原料为有机杀菌剂或中间体。制备的R - CDs不仅具有内在的抗菌活性，还能通过产生活性氧有效地杀死多重耐药细菌（多重耐药鲍曼不动杆菌（MRAB）和耐甲氧西林金黄色葡萄球菌（MRSA））。此外，R - CDs可以消除和抑制MRAB生物膜的形成，同时对正常细胞几乎没有副作用。在治疗对抗生素敏感的MRAB引起的感染伤口时，R - CDs展现出独特的性能。这些数据表明，这种基于新型R - CDs的策略可能有助于设计下一代抗耐药细菌的药物。
本文的补充材料可在10.1007/s40843 - 021 - 1770 - 0获取，授权用户可访问。
