Krøigård Thomas, Gylfadottir Sandra S, Itani Mustapha, Khan Karolina S, Andersen Henning, Sindrup Søren H, Jensen Troels S, Andersen Kjeld V, Tankisi Hatice, Beniczky Sándor, Kristensen Alexander Gramm
Research Unit for Neurology, Odense University Hospital, Odense, Denmark.
University of Southern Denmark, Odense, Denmark.
Clin Neurophysiol Pract. 2021 Sep 2;6:239-243. doi: 10.1016/j.cnp.2021.08.001. eCollection 2021.
Dorsal sural nerve conduction studies (NCS) may increase the sensitivity for the diagnosis of polyneuropathy, but clinical use is limited by a lack of reliable normative reference values in all age-groups. The aim of our study was to develop reference values for the dorsal sural nerve, based on a large multicenter cohort of healthy subjects.
Bilateral antidromic NCS were performed using standard surface electrodes in 229 healthy subjects (aged 21-80 years; median: 54 years). We assessed the normality of data distribution for amplitudes and conduction velocity (CV) and for their logarithmic (ln) transformation. The effects of age and height were determined using linear regression analysis.
Sensory potentials were present in all subjects. Logarithmically transformed data were normally distributed. Age and height were most significantly associated with amplitude, and age and height with CV, respectively. There was no significant side-difference. Mean amplitudes (right and left) were 4.8 and 4.9 μV and mean CV 46.7 and 46.9 m/s. Reference limits were e for amplitude and e for CV.
Dorsal sural nerve NCS are robust and have well defined normative limits.
The findings provide a basis for more sensitive NCS in clinical practice and future studies of the diagnostic accuracy of NCS in polyneuropathy.
腓肠背侧神经传导研究（NCS）可能会提高多发性神经病诊断的敏感性，但由于缺乏所有年龄组可靠的正常参考值，其临床应用受到限制。我们研究的目的是基于一个大型多中心健康受试者队列制定腓肠背侧神经的参考值。
使用标准表面电极对229名健康受试者（年龄21 - 80岁；中位数：54岁）进行双侧逆向NCS。我们评估了振幅和传导速度（CV）及其对数（ln）转换数据分布的正态性。使用线性回归分析确定年龄和身高的影响。
所有受试者均存在感觉电位。对数转换后的数据呈正态分布。年龄和身高分别与振幅和CV最显著相关。左右侧无显著差异。平均振幅（右侧和左侧）分别为4.8和4.9 μV，平均CV分别为46.7和46.9 m/s。振幅的参考限值为e ，CV的参考限值为e 。
腓肠背侧神经NCS可靠且具有明确的正常限值。
这些发现为临床实践中更敏感的NCS以及未来关于NCS在多发性神经病诊断准确性的研究提供了基础。
